Verbal memory dysfunction is common in focal, drug-resistant epilepsy (DRE). Unfortunately, surgical removal of seizure-generating brain tissue can be associated with further memory decline. Therefore, localization of both the circuits generating seizures and those underlying cognitive functions is critical in presurgical evaluations for patients who may be candidates for resective surgery. We used intracranial electroencephalographic (iEEG) recordings during a verbal memory task to investigate word encoding in focal epilepsy. We hypothesized that engagement in a memory task would exaggerate local iEEG feature differences between the seizure onset zone (SOZ) and neighboring tissue as compared to wakeful rest (“nontask”).

中文翻译：

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利用词编码的电生理相关性来绘制局灶性癫痫发作发作区：癫痫样活动、光谱特征和功能连接的任务依赖性变化

言语记忆功能障碍在局灶性耐药性癫痫 (DRE) 中很常见。不幸的是，手术切除引起癫痫发作的脑组织可能会导致记忆力进一步下降。因此，定位产生癫痫发作的回路和潜在的认知功能对于可能适合进行切除手术的患者的术前评估至关重要。我们在口头记忆任务期间使用颅内脑电图 (iEEG) 记录来研究局灶性癫痫中的单词编码。我们假设与清醒休息（“非任务”）相比，参与记忆任务会夸大癫痫发作区（SOZ）和邻近组织之间的局部 iEEG 特征差异。