Two coordination polymers, that is [Zn(pdc)(im)(H₂O)]_n (1) and [Cu(pdc)(im)₂]_n·n(H₂pdc) (2) (H₂pdc = terephthalic acid, im = imidazole), were hydrothermally synthesized via the reactions of H₂pdc and im in combination with Zn(II) or Cu(II) ions. Compound 1 shows intense blue luminescence and compound 2 shows good photocatalytic activity for the methyl violet degradation under the irradiation of ultraviolet light. In addition, the assessment of the two compounds’ application values against Parkinson's disease were carried out and their specific mechanism was tested simultaneously. First of all, the real time RT-PCR was implemented and the relative expression levels of N-methyl-D-aspartic acid receptor receptor on neurons were measured. Besides, the Annexin V-FITC/PI apoptosis assay was utilized for the assessment of the influence of the compounds on the dopaminergic neuron death rate. The hemolysis toxicity detection was conducted to detect the biocompatible of the compounds.

两种配位聚合物，即 [Zn(pdc)(im)(H ₂ O)] _n ( 1 ) 和 [Cu(pdc)(im) ₂ ] _n ·n(H ₂ pdc) ( 2 ) (H ₂ pdc = 对苯二甲酸，im = 咪唑），通过 H ₂ pdc 和 im 与 Zn(II) 或 Cu(II) 离子的反应水热合成。化合物1显示强烈的蓝色发光，化合物2在紫外光照射下对甲基紫的降解表现出良好的光催化活性。此外，还对这两种化合物对帕金森病的应用价值进行了评价，同时对它们的具体作用机制进行了测试。首先，实施实时RT-PCR，测定神经元上N-甲基-D-天冬氨酸受体的相对表达水平。此外，膜联蛋白 V-FITC/PI 细胞凋亡测定用于评估化合物对多巴胺能神经元死亡率的影响。进行溶血毒性检测以检测化合物的生物相容性。