Gut barrier and microbiota changes with glycine and branched-chain amino acid supplementation in chronic haemodialysis patients,Journal of Cachexia, Sarcopenia and Muscle

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Gut barrier and microbiota changes with glycine and branched-chain amino acid supplementation in chronic haemodialysis patients
Journal of Cachexia, Sarcopenia and Muscle ( IF 8.9 ) Pub Date : 2021-09-18 , DOI: 10.1002/jcsm.12781
Laurence Genton ₁ , Menno Pruijm ₂ , Daniel Teta ₃ , Isabelle Bassi ₃ , Patrice D Cani ₄ , Nadia Gaïa ₅ , François R Herrmann ₆ , Nicola Marangon ₇ , Julie Mareschal ₁ , Giulio G Muccioli ₈ , Catherine Stoermann ₉ , Francesco Suriano ₄ , Arlene Wurzner-Ghajarzadeh ₂ , Vladimir Lazarevic ₅ , Jacques Schrenzel ₅

Affiliation

Unit of Nutrition, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Service of Nephrology, University Hospitals of Lausanne and University of Lausanne, Lausanne, Switzerland.
Service of Nephrology, Cantonal Hospital of Sion, Sion, Switzerland.
Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), Université catholique de Louvain, Brussels, Belgium.
Genomic Research Lab and Service of Infectious Diseases, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Service of Nephrology, Geneva University Hospitals and Clinique of Champel, Geneva, Switzerland.
Louvain Drug Research Institute, Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Université catholique de Louvain, Brussels, Belgium.
Service of Nephrology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

We have previously shown that glycine increases fat-free mass in chronic haemodialysis patients with features of malnutrition as compared with branched-chain amino acids (BCAAs). This multicentre randomized double-blind crossover study evaluates the impact of these amino acids on the gut barrier and microbiota.

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