Syngeneic mouse models are tumors derived from murine cancer cells engrafted on genetically identical mouse strains. They are widely used tools for studying tumor immunity and immunotherapy response in the context of a fully functional murine immune system. Large volumes of syngeneic mouse tumor expression profiles under different immunotherapy treatments have been generated, although a lack of systematic collection and analysis makes data reuse challenging. We present Tumor Immune Syngeneic MOuse (TISMO), a database with an extensive collection of syngeneic mouse model profiles with interactive visualization features. TISMO contains 605 in vitro RNA-seq samples from 49 syngeneic cancer cell lines across 23 cancer types, of which 195 underwent cytokine treatment. TISMO also includes 1518 in vivo RNA-seq samples from 68 syngeneic mouse tumor models across 19 cancer types, of which 832 were from immune checkpoint blockade (ICB) studies. We manually annotated the sample metadata, such as cell line, mouse strain, transplantation site, treatment, and response status, and uniformly processed and quality-controlled the RNA-seq data. Besides data download, TISMO provides interactive web interfaces to investigate whether specific gene expression, pathway enrichment, or immune infiltration level is associated with differential immunotherapy response. TISMO is available at http://tismo.cistrome.org.

中文翻译：

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TISMO：用于模拟肿瘤免疫和免疫治疗反应的同基因小鼠肿瘤数据库

同基因小鼠模型是源自移植在基因相同的小鼠品系上的小鼠癌细胞的肿瘤。它们是在功能齐全的小鼠免疫系统背景下研究肿瘤免疫和免疫治疗反应的广泛使用的工具。尽管缺乏系统的收集和分析使得数据重用具有挑战性，但已经生成了在不同免疫疗法治疗下的大量同源小鼠肿瘤表达谱。我们介绍了肿瘤免疫同基因小鼠 (TISMO)，这是一个数据库，其中包含大量具有交互式可视化功能的同基因小鼠模型配置文件。TISMO 包含来自 23 种癌症类型的 49 个同基因癌细胞系的 605 个体外 RNA-seq 样本，其中 195 个接受了细胞因子治疗。TISMO 还包括来自 19 种癌症类型的 68 个同基因小鼠肿瘤模型的 1518 个体内 RNA-seq 样本，其中 832 个来自免疫检查点阻断 (ICB) 研究。我们手动标注样本元数据，如细胞系、小鼠品系、移植部位、治疗和反应状态，并对 RNA-seq 数据进行统一处理和质量控制。除了数据下载之外，TISMO 还提供交互式网络界面来研究特定基因表达、通路富集或免疫浸润水平是否与差异免疫治疗反应相关。TISMO 可在 http://tismo.cistrome.org 获得。并对 RNA-seq 数据进行统一处理和质量控制。除了数据下载之外，TISMO 还提供交互式网络界面来研究特定基因表达、通路富集或免疫浸润水平是否与差异免疫治疗反应相关。TISMO 可在 http://tismo.cistrome.org 获得。并对 RNA-seq 数据进行统一处理和质量控制。除了数据下载之外，TISMO 还提供交互式网络界面来研究特定基因表达、通路富集或免疫浸润水平是否与差异免疫治疗反应相关。TISMO 可在 http://tismo.cistrome.org 获得。