Background

Plasma ghrelin levels can be elevated in patients with acute heart failure (AHF). This study aimed to analyze the temporal changes and prognostic value of ghrelin levels in patients with AHF.

Methods

This prospective study included patients with AHF at the Cardiology Department, Weifang People’s Hospital (May 2018–October 2019), and age- and sex-matched healthy controls. Plasma ghrelin levels were measured. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were used to evaluate whether ghrelin levels could predict major cardiac adverse events (MACEs) during a 1-year follow-up.

Results

Finally, 92 patients with AHF and 50 healthy controls were enrolled. Ghrelin levels were higher in patients with AHF at 1, 3, 12, and 24 h compared with controls (all P < 0.01). Ghrelin levels in the AHF group were higher at 3 and 12 h than at 1 and 24 h (P < 0.001). Ghrelin level at 3 h in patients with AHF was negatively correlated with the left ventricular end-diastolic diameter and left ventricular ejection fraction (both P < 0.05). MACEs occurred in 48 patients with AHF. Ghrelin levels were higher in the MACE group than in the non-MACE group at 1 (P = 0.011) and 3 h (P = 0.034). Multivariable regression showed that ghrelin level at 3 h was independently associated with MACEs [OR = 0.629, 95% confidence interval (CI): 0.515–0.742, P = 0.010], but the area under the ROC curve was only 0.629 (95% CI 0.515–0.742).

Conclusions

Plasma ghrelin levels are elevated in AHF and patients with MACEs during follow-up.

中文翻译：

---

急性心力衰竭患者血浆 ghrelin 水平的时间变化及预后价值：一项前瞻性研究

背景

急性心力衰竭 (AHF) 患者的血浆 ghrelin 水平可能会升高。本研究旨在分析 AHF 患者 ghrelin 水平的时间变化和预后价值。

方法

这项前瞻性研究包括潍坊市人民医院心内科（2018 年 5 月至 2019 年 10 月）的 AHF 患者以及年龄和性别匹配的健康对照。测量血浆生长素释放肽水平。多变量逻辑回归和受试者工作特征 (ROC) 曲线分析用于评估 ghrelin 水平是否可以预测 1 年随访期间的主要心脏不良事件 (MACE)。

结果

最后，纳入了 92 名 AHF 患者和 50 名健康对照者。与对照组相比，AHF 患者 1、3、12 和 24 小时的 Ghrelin 水平较高（均P  < 0.01）。AHF 组 3 小时和 12 小时的 Ghrelin 水平高于 1 小时和 24 小时（P  < 0.001）。AHF患者3 h Ghrelin水平与左心室舒张末期直径和左心室射血分数呈负相关（均P  < 0.05）。48 名 AHF 患者发生 MACE。MACE 组的 Ghrelin 水平在 1 ( P  = 0.011) 和 3 h ( P = 0.034)。多变量回归显示，3 h ghrelin 水平与 MACE 独立相关 [OR = 0.629, 95% 置信区间 (CI): 0.515–0.742, P  = 0.010]，但 ROC 曲线下面积仅为 0.629 (95% CI 0.515–0.742）。

结论

在随访期间，AHF 和 MACE 患者的血浆 ghrelin 水平升高。