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Development and characterization of a unique anti-IgE mouse monoclonal antibody cross-reactive between human and canine IgE
Immunity, Inflammation and Disease ( IF 2.493 ) Pub Date : 2021-09-17 , DOI: 10.1002/iid3.531
Akiko Kumagai 1 , Takuya Nara 1, 2 , Mizuho Uematsu 1 , Yoko Kakinuma 1 , Takashi Saito 2 , Kenichi Masuda 1, 2
Affiliation  

The efficacy assessment of human anti-IgE monoclonal antibodies (mAbs) in animal models before clinical trials is hampered due to the lack of cross-reactivity of anti-IgE mAbs between species.

中文翻译:

人与犬 IgE 交叉反应的独特抗 IgE 小鼠单克隆抗体的开发和表征

由于缺乏抗 IgE 单克隆抗体在物种之间的交叉反应性,在临床试验前在动物模型中评估人抗 IgE 单克隆抗体 (mAb) 的功效受到阻碍。
更新日期:2021-11-13
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