To evaluate the combined impact of male and female BMI on cumulative pregnancy outcomes after the first ovarian stimulation.

Retrospective cohort study.

University-affiliated reproductive medicine center.

A total of 15,972 couples undergoing their first ovarian stimulations from June 2009 to June 2016 were included. During the follow-up period between June 2009 and June 2018, 14,182 couples underwent a complete ART cycle involving fresh embryo transfer and subsequent frozen embryo transfers (FETs) after their first ovarian stimulations. Patients with a BMI <24 kg/m² served as the reference group. Patients with a BMI ≥ 24 kg/m² were considered to be overweight, and those with a BMI ≥28 kg/m² were considered to be obese.

None.

The primary outcome was the cumulative live birth rate (CLBR), which defined as the delivery of at least one live birth in the fresh or in the subsequent FET cycles after the first ovarian stimulation.

In the analyses of females and males separately, compared with the reference group, overweight and obese females had a reduced CLBR (aOR 0.83, 95% CI 0.7.92 and aOR 0.76, 95% CI 0.64–0.90). Similarly, overweight males had a reduced CLBR (aOR 0.91, 95% CI 0.83–0.99) compared with that of the reference group. In the analyses of couples, those in which the male was in the reference or overweight group and the female was overweight or obese had a significantly lower CLBR than those in which both the male and female had a BMI <24 kg/m².

The CLBR is negatively impacted by increased BMI in the female and overweight status in the male, both individually and together.

评估男性和女性 BMI 对第一次卵巢刺激后累积妊娠结局的综合影响。

回顾性队列研究。

大学附属生殖医学中心。

从 2009 年 6 月到 2016 年 6 月，共有 15,972 对夫妇接受了第一次卵巢刺激。在 2009 年 6 月至 2018 年 6 月的随访期间，14,182 对夫妇在第一次卵巢刺激后接受了完整的 ART 周期，包括新鲜胚胎移植和随后的冷冻胚胎移植 (FET)。^{BMI <24 kg/m 2}的患者作为参考组。BMI≥24 kg/m ²的患者被认为是超重， BMI ≥28 kg/m ²的患者被认为是肥胖。

没有任何。

主要结果是累积活产率 (CLBR)，其定义为在第一次卵巢刺激后的新鲜或随后的 FET 周期中分娩至少一个活产。

在分别对女性和男性进行的分析中，与参考组相比，超重和肥胖女性的 CLBR 降低（aOR 0.83, 95% CI 0.7.92 和 aOR 0.76, 95% CI 0.64-0.90）。同样，与参考组相比，超重男性的 CLBR 降低（aOR 0.91, 95% CI 0.83-0.99）。在对夫妇的分析中，男性在参考组或超重组且女性超重或肥胖的夫妇的 CLBR 显着低于男性和女性 BMI <24 kg/m ²的夫妇。

CLBR 受到女性 BMI 增加和男性超重状态的负面影响，无论是单独还是共同。