Frontiers in Endocrinology ( IF 5.2 ) Pub Date : 2021-09-17 , DOI: 10.3389/fendo.2021.709564 Agnieszka Zubkiewicz-Kucharska 1 , Beata Wikiera 1 , Anna Noczyńska 1
Klotho concentration may be considered as a prognostic factor in the development of chronic complications of diabetes. Moreover, decrease in sKlotho concentration may contribute to beta cell apoptosis and type 1 diabetes development. The aim of this study was to evaluate if sKlotho protein concentration in children with type 1 diabetes (T1D) and its correlation with classical risk factors of chronic complications of diabetes: dysglycemia and endothelial dysfunction.
In a cross-section single center study the levels of soluble Klotho protein in 80 T1D (37 boys) and 34 healthy children (controls, 15 boys). Micro- and macroangiopathy were excluded and renal function was normal in all participants. Serum sKlotho, sICAM-1, sVCAM-1 and E-selectin levels were measured.
The concentration of sKlotho was lower in T1D than in the controls (2041.9 ± 1017.6 pg/mL
This study reports the significantly lower level of s-Klotho in children with type 1 diabetes, correlated with HbA1c and HDL cholesterol, but not with the adhesion molecules concentrations nor the duration of the disease. Negative correlation between the levels of HbA1c and soluble Klotho may suggest its possible involvement in the development of chronic diabetes complications.
中文翻译:
1 型糖尿病儿童的可溶性 Klotho 减少并与代谢控制相关
Klotho 浓度可能被认为是糖尿病慢性并发症发展的预后因素。此外,sKlotho 浓度的降低可能有助于 β 细胞凋亡和 1 型糖尿病的发展。本研究的目的是评估 1 型糖尿病 (T1D) 儿童的 sKlotho 蛋白浓度及其与糖尿病慢性并发症的经典危险因素的相关性:血糖异常和内皮功能障碍。
在一项横断面单中心研究中,对 80 名 T1D(37 名男孩)和 34 名健康儿童(对照组,15 名男孩)的可溶性 Klotho 蛋白水平进行了研究。排除了微血管病和大血管病,所有参与者的肾功能均正常。测量了血清 sKlotho、sICAM-1、sVCAM-1 和 E-选择素水平。
T1D 中 sKlotho 的浓度低于对照组 (2041.9 ± 1017.6 pg/mL
这项研究报告了 1 型糖尿病儿童的 s-Klotho 水平显着降低,这与 HbA1c 和 HDL 胆固醇相关,但与粘附分子浓度和疾病持续时间无关。HbA1c 水平与可溶性 Klotho 水平之间的负相关可能表明其可能参与慢性糖尿病并发症的发展。