Calcific aortic stenosis is a progressive disease that has become more prevalent in recent decades. Despite advances in research to uncover underlying biomechanisms, and development of new generations of prosthetic valves and replacement techniques, management of calcific aortic stenosis still comes with unresolved complications. In this review, we highlight underlying molecular mechanisms of acquired aortic stenosis calcification in relation to hemodynamics, complications related to the disease, diagnostic methods, and evolving treatment practices for calcific aortic stenosis.

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钙化性主动脉瓣狭窄——获得性发病机制及治疗的综述

钙化性主动脉瓣狭窄是一种进行性疾病，近几十年来变得越来越普遍。尽管在揭示潜在生物机制的研究方面取得了进展，并且开发了新一代人工瓣膜和置换技术，但钙化性主动脉瓣狭窄的管理仍然伴随着未解决的并发症。在这篇综述中，我们重点介绍了获得性主动脉瓣狭窄钙化与血流动力学、与疾病相关的并发症、诊断方法和钙化性主动脉瓣狭窄不断发展的治疗实践相关的潜在分子机制。