Introduction: Wheezing is a common problem in preschool children. Currently, there are no reliable biomarkers that can predict subsequent wheezing in preschool children. This study aimed to compare serum periostin levels between preschool children with and without recurrent wheezing and investigate its utility for predicting acute wheezing exacerbation. Methods: Children aged 2–5 years with recurrent wheezing and healthy control children were enrolled. They were evaluated for serum periostin level at enrollment and subsequently followed for wheezing episodes in a 1-year prospective study. Results: A total of 122 children were enrolled. Children in the recurrent wheezing group (n = 80) had a greater median serum periostin level (1,122.32 pg/mL [#x3c;10–6,978.93]) than that of the healthy control group (n = 40) (#x3c;10 pg/mL [#x3c;10–2,116.69]), p value = 0.006. After 1-year follow-up, subjects who experienced subsequent wheezing exacerbation episodes had a greater median of periostin level (5,321 pg/mL) compared with those with no exacerbation (#x3c;10 pg/mL), p value = 0.014. ROC curve analysis revealed that the level of serum periostin #x3e;1,200 pg/mL, corresponding to 78.9% sensitivity and 64.6% specificity, with an AUC of 0.701, p value = 0.009, could be a predictor for acute wheezing exacerbation within 1 year. Besides, subjects with serum periostin #x3e;1,200 pg/mL had greater odds of subsequent wheezing episodes compared with those with lower levels of serum periostin (adjusted odds ratio 10.0, 95% confidence interval: 2.3–43.5). Conclusions: Preschool children with recurrent wheezing have a greater serum periostin level than healthy control. Serum periostin may be a valuable biomarker for predicting acute wheezing exacerbations in the following year.
Int Arch Allergy Immunol

中文翻译：

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血清骨膜素可预测喘息恶化：一项针对反复喘息的学龄前儿童的前瞻性研究

简介：喘息是学龄前儿童的常见问题。目前，没有可靠的生物标志物可以预测学龄前儿童随后的喘息。本研究旨在比较有和没有反复喘息的学龄前儿童的血清骨膜素水平，并探讨其预测急性喘息恶化的效用。方法：招募2~5岁反复喘息儿童和健康对照儿童。他们在入组时评估了血清骨膜素水平，随后在一项为期 1 年的前瞻性研究中跟踪了喘息发作。结果：共有122名儿童入组。反复喘息组儿童（ n= 80) 的血清骨膜素水平中位数 (1,122.32 pg/mL [#x3c;10–6,978.93]) 高于健康对照组 ( n = 40) (#x3c;10 pg/mL [#x3c;10– 2,116.69]），p值 = 0.006。在 1 年的随访后，与未发作的受试者相比（#x3c；10 pg/mL），经历后续喘息加重发作的受试者的骨膜素水平中位数（5,321 pg/mL）更高，p值 = 0.014。ROC 曲线分析显示血清骨膜素水平 #x3e;1,200 pg/mL，对应于 78.9% 的敏感性和 64.6% 的特异性，AUC 为 0.701，p值 = 0.009，可能是 1 年内急性喘息恶化的预测指标。此外，血清骨膜素#x3e;1,200 pg/mL 的受试者与血清骨膜素水平较低的受试者相比，随后发生喘息的几率更大（调整优势比 10.0，95% 置信区间：2.3-43.5）。结论：学龄前儿童反复喘息的血清骨膜素水平高于健康对照组。血清骨膜素可能是一种有价值的生物标志物，可用于预测下一年的急性喘息加重。
Int Arch 过敏免疫