Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a recently defined tumor subtype with apparent favorable clinical outcome despite aggressive histomorphology. However, in recent years, additional numbers of cases, with more variable features and at locations outside the sinonasal region, have complicated the definition of HMSC. Here, we have performed a systematic review of all cases described so far in order to accumulate more knowledge. We identified 127 articles published between 2013 and 2021, of which 21 presented unique cases. In total, 79 unique patient cases were identified and their clinical and micromorphological nature are herein summarized. In our opinion, better clinical follow-up data and a more detailed tumor characterization are preferably needed before HMSC can finally be justified as its own tumor entity.

中文翻译：

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人乳头瘤病毒相关多表型鼻窦癌——更广泛的肿瘤实体？

人乳头瘤病毒 (HPV) 相关的多表型鼻窦癌 (HMSC) 是一种最近定义的肿瘤亚型，尽管具有侵袭性的组织形态学，但具有明显的良好临床结果。然而，近年来，更多的病例，具有更多的可变特征和位于鼻窦区域以外的位置，使得 HMSC 的定义变得复杂。在这里，我们对迄今为止描述的所有案例进行了系统回顾，以积累更多知识。我们确定了 2013 年至 2021 年间发表的 127 篇文章，其中 21 篇介绍了独特的案例。总共确定了 79 例独特的患者病例，并在此总结了它们的临床和微形态学性质。在我们看来，