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Dynamic responses of neurons in different states under magnetic field stimulation
Journal of Computational Neuroscience ( IF 1.2 ) Pub Date : 2021-09-16 , DOI: 10.1007/s10827-021-00796-3
Huilan Yang 1 , Hongbin Wang 1 , Lei Guo 1 , Guizhi Xu 1
Affiliation  

Transcranial magnetic stimulation (TMS) is an effective method to treat neurophysiological disorders by modulating the electrical activities of neurons. Neurons can exhibit complex nonlinear behaviors underlying the external stimuli. Currently, we do not know how stimulation interacts with endogenous neural activity. In this paper, the effects of magnetic field on spiking neuron, bursting neuron and bistable neuron are studied based on the Hodgkin–Huxley (HH) neuron model. The results show that the neurons in three different states can exhibit different dynamic responses under magnetic field stimulation. The magnetic field stimulation could increase or decrease the firing frequencies of spiking neuron, bursting neuron and bistable neuron. The transitions between different firing patterns of neurons can be promoted by changing the parameters of the magnetic field. Magnetic field stimulation has a minimal impact on the firing temporal sequence sequences in bursting neuron than that in spiking neuron and bistable neuron. These results provided an insight into the impact of neuronal states on neuronal dynamic responses under brain stimulation and show that subtle changes in external conditions and stimuli can cause complex neuronal responses. This study can help us understand the state-dependent coding mechanism of neurons under electromagnetic stimulation.



中文翻译:

磁场刺激下不同状态神经元的动态反应

经颅磁刺激(TMS)是一种通过调节神经元电活动来治疗神经生理障碍的有效方法。神经元可以在外部刺激下表现出复杂的非线性行为。目前,我们不知道刺激如何与内源性神经活动相互作用。本文基于霍奇金-赫胥黎(HH)神经元模型研究了磁场对脉冲神经元、爆发神经元和双稳态神经元的影响。结果表明,三种不同状态的神经元在磁场刺激下可以表现出不同的动态响应。磁场刺激可以增加或减少脉冲神经元、爆发神经元和双稳态神经元的放电频率。通过改变磁场的参数,可以促进神经元不同放电模式之间的转换。与脉冲神经元和双稳态神经元相比,磁场刺激对爆发神经元的放电时间序列的影响最小。这些结果提供了对大脑刺激下神经元状态对神经元动态反应的影响的深入了解,并表明外部条件和刺激的细微变化会导致复杂的神经元反应。本研究可以帮助我们了解电磁刺激下神经元的状态依赖编码机制。这些结果提供了对大脑刺激下神经元状态对神经元动态反应的影响的深入了解,并表明外部条件和刺激的细微变化会导致复杂的神经元反应。本研究可以帮助我们了解电磁刺激下神经元的状态依赖编码机制。这些结果提供了对大脑刺激下神经元状态对神经元动态反应的影响的深入了解,并表明外部条件和刺激的细微变化会导致复杂的神经元反应。本研究可以帮助我们了解电磁刺激下神经元的状态依赖编码机制。

更新日期:2021-09-17
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