Mini-Reviews in Organic Chemistry ( IF 2.3 ) Pub Date : 2021-08-31 , DOI: 10.2174/1570193x17999200911113127 Krysthal Marrie dos Santos 1 , Jorge de Lima Neto 1 , Luis Paulo Alves da Silva 1 , Analú Campos Reis 1 , Ricardo Silva Porto 1 , Dimas José da Paz Lima 1 , Antônio Euzébio Goulart Santana 2
This paper presents a short review of synthetic approaches aiming to synthesise (+)- Grandisol, the main constituent of grandlure, a pheromone mixture released by the boll weevil, which is proven to exhibit significant biological activity. (+)-Grandisol 1 is among the components of the male-produced pheromone of the boll weevil Anthonomuns grandis, an important pest of cotton crops in Mesoamerica (from the south USA to Argentina). As a result of its biological activity and unique structure, several synthetic approaches have been reported. The aim is to explore remarkable methodologies towards the synthesis of (+)-Grandisol 1. Several methodologies have been applied towards the synthesis of (+)-Grandisol 1, including classical methods for cyclobutane ring construction, which promoted substantial improvements to access this pheromone, as well as a better comprehension of its biological profile.
中文翻译:
(+)-Grandisol 的合成策略,棉铃象鼻虫信息素的主要成分
本文简要回顾了旨在合成 (+)- Grandisol 的合成方法,这是 Grandlure 的主要成分,是一种由棉铃象鼻虫释放的信息素混合物,已被证明具有显着的生物活性。(+)-Grandisol 1 是棉铃象鼻虫雄性产生的信息素的成分之一,棉铃象鼻虫是中美洲(从美国南部到阿根廷)棉花作物的重要害虫。由于其生物活性和独特的结构,已经报道了几种合成方法。目的是探索合成 (+)-Grandisol 1 的非凡方法。 几种方法已应用于 (+)-Grandisol 1 的合成,包括环丁烷环构建的经典方法,这促进了获取该信息素的实质性改进,