Journal of Natural Medicines ( IF 3.3 ) Pub Date : 2021-09-17 , DOI: 10.1007/s11418-021-01567-1 Yasinjan Hashim 1 , Kazufumi Toume 1 , Shusaku Mizukami 2, 3, 4 , Toshinori Kitami 1 , Mayumi Taniguchi 2, 4 , Awet Alem Teklemichael 2, 5 , Yuki Tayama 2, 5 , Nguyen Tien Huy 2, 3, 6 , José Nzunzu Lami 7 , Joseph M Bodi 8 , Kenji Hirayama 2, 5, 6 , Katsuko Komatsu 1
Three phenylpropanoid-conjugated iridoid glucosides, acetylgaertneric acid (1), acetyldehydrogaertneroside (2), and dehydrogaertneric acid (10), together with nine known related iridoid glucosides (3–9, 11, and 12), two coumaroyl alkaloids, one benzenoid, and three flavonoid glucosides were isolated from leaves of Morinda morindoides (Rubiaceae). Structures of these isolated compounds were determined using spectroscopic analysis. Compounds 1–18 and previously isolated compounds (19–29) were evaluated for anti-trypanosomal activity against Trypanosoma cruzi Tulahuen strain (trypomastigote and amastigote) together with cytotoxicity against host cells, new-born mouse heart cells. Among them, molucidin (21) and prismatomerin (22) exhibited good anti-trypanosomal activity (IC50 of 4.67 and 5.70 µM, respectively), together with cytotoxicity (CC50 of 2.76 and 3.22 μM, respectively). Compounds 1–18 did not show anti-malarial activity against a chloroquine/mefloquine-sensitive strain of Plasmodium falciparum.
中文翻译:
来自巴戟天叶片的苯丙烷共轭环烯醚萜苷
三苯丙共轭的环烯醚萜苷,acetylgaertneric酸(1),acetyldehydrogaertneroside(2),和dehydrogaertneric酸(10),具有九个已知相关环烯醚萜苷(一起3 - 9,11,和12),两个香豆生物碱,一个苯,从巴戟天(茜草科)的叶子中分离出三种黄酮苷。使用光谱分析确定这些分离的化合物的结构。化合物1 – 18和先前分离的化合物 ( 19 – 29) 对克氏锥虫Tulahuen 菌株(trypomastigote 和 amastigote)的抗锥虫活性以及对宿主细胞、新生小鼠心脏细胞的细胞毒性进行了评估。其中,molucidin ( 21 ) 和 prismatomerin ( 22 ) 表现出良好的抗锥虫活性(IC 50 分别为 4.67 和 5.70 µM)以及细胞毒性(CC 50 分别为 2.76 和 3.22 µM)。化合物1 - 18没有表现出反对的氯/甲氟喹敏感株的抗疟活性恶性疟原虫。