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Recent advances in catalytic synthesis of medium-ring lactones and their derivatives
Catalysis Science & Technology ( IF 5 ) Pub Date : 2021-09-01 , DOI: 10.1039/d1cy01438b
Zi-Kui Liu 1 , Yang Gao 2 , Xiao-Qiang Hu 1
Affiliation  

Medium-sized lactones are widely found in various natural products and pharmaceuticals. However, the efficient synthesis of these structures remains as a challenging topic in organic synthesis due to the disfavored kinetic and thermodynamic factors. The recent development of palladium-catalysed dipolar cycloaddition, electrophilic halolactonization, NHC-catalysed cyclization, ring expansion reactions, transition metal-catalysed coupling reactions, etc. provides a powerful platform for the construction of these important scaffolds. In light of the ever-increasing significance of medium-sized lactones across a range of chemical sciences, the present review aims to summarize the main achievements in the field of catalytic synthesis of medium-ring lactones with emphasis on reaction mechanism and scope as well as synthetic application.

中文翻译:

中环内酯及其衍生物催化合成新进展

中等大小的内酯广泛存在于各种天然产品和药物中。然而,由于不利的动力学和热力学因素,这些结构的有效合成仍然是有机合成中的一个具有挑战性的课题。钯催化偶极环加成、亲电卤代内酯化、NHC催化环化、扩环反应、过渡金属催化偶联反应的最新进展为构建这些重要的脚手架提供了强大的平台。鉴于中环内酯在一系列化学科学中的重要性日益增加,本综述旨在总结中环内酯催化合成领域的主要成就,重点介绍反应机理和范围以及合成应用。
更新日期:2021-09-17
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