Nature offers plenty of opportunities to the researchers of different communities to explore heterocyclic compounds. Among the various magic heterocyclic scaffolds, chromane and chromanone are the most privileged heterocycles due to their omnipresence in most value-added chemical entities. On the other hand, spirocyclic heterocyclic moieties offer unique three-dimensional frameworks which can fit into the cavity of the proteins, including enzymes, thereby enhancing the biological properties. Considering the remarkable significance of spirocyclic systems of chromanes and chromanones, various novel strategies such as Kabbe condensation, organocatalyzed reactions, oxa/sulfa-Michael-Aldol cascade reaction, oxa-Michael/addition and 1,3-dipolar cycloaddition, among others, have emerged to access this precious heterocyclic architecture in good to excellent yields. This review summarizes the synthesis of a variety of spirochromane and spirochromanone derivatives covering the literature from 1991-2020.


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螺色满酮及其衍生物的合成新进展

大自然为不同社区的研究人员提供了大量探索杂环化合物的机会。在各种神奇的杂环支架中，色烷和色满酮是最具特权的杂环，因为它们在大多数增值化学实体中无处不在。另一方面，螺环杂环部分提供了独特的三维框架，可以适应蛋白质（包括酶）的空腔，从而增强生物学特性。考虑到色烷和色满酮的螺环体系的显着意义，各种新颖的策略，如卡贝缩合、有机催化反应、氧杂/磺胺-迈克尔-羟醛级联反应、氧杂-迈克尔/加成和 1,3-偶极环加成等，已经出现以良好至极好的收率获得这种珍贵的杂环结构。本综述总结了 1991-2020 年文献中各种螺色烷和螺色酮衍生物的合成。