Stress-related mechanisms are implicated in the pathophysiology of bipolar disorder and may contribute to heterogeneity in illness course. Yet, there is a lack of study investigating the neural mechanisms underlying the stress response in this condition. This study investigated changes in amygdala activation and functional connectivity in response to acute psychosocial stress in young adults with bipolar disorder and explored relations with clinical phenotype and prospective mood symptoms.

中文翻译：

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患有双相情感障碍的年轻成人的心理社会压力的神经功能连接变化以及与临床轨迹的初步关联

与压力相关的机制与双相情感障碍的病理生理学有关，并可能导致病程的异质性。然而，缺乏研究调查这种情况下应激反应的神经机制。本研究调查了患有双相情感障碍的年轻成人在应对急性社会心理压力时杏仁核激活和功能连接的变化，并探讨了其与临床表型和预期情绪症状的关系。