An enzyme responsive supramolecular prodrug with near-infrared targeted cell imaging property was successfully constructed. Cell experiments indicated that the prodrug nanoparticles are easily internalized into cancer cells via receptor-mediated endocytosis and disassembled under the action of butyrylcholinesterase by cutting the ester bond of prodrug, exhibiting a controlled drug release behavior as well as a simultaneous near-infrared (NIR) fluorescence imaging in cancer cells.

中文翻译：

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具有靶向近红外细胞成像特性的丁酰胆碱酯酶反应性超分子前药

成功构建了具有近红外靶向细胞成像特性的酶响应超分子前药。细胞实验表明，前药纳米颗粒通过受体介导的内吞作用很容易内化到癌细胞中，并在丁酰胆碱酯酶的作用下通过切割前药的酯键分解，表现出受控的药物释放行为以及同步近红外（NIR）癌细胞中的荧光成像。