A novel protein nanocage has been developed capable of on-demand reversible disassembly via simple buffer exchanges under mild conditions. Data presented herein also show the nanocage is capable of in vivo and in vitro cargo loading, suggesting a broad range of possible applications in biocatalysis, bionanotechnology, and biomedicine. Additional findings include structure determination and protein design verification via cryo-electron microscopy.

中文翻译：

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工程蛋白质纳米笼的触发可逆分解**

已经开发出一种新型蛋白质纳米笼，能够在温和条件下通过简单的缓冲液交换实现按需可逆拆卸。本文提供的数据还表明，纳米笼能够在体内和体外装载货物，表明在生物催化、生物纳米技术和生物医学中具有广泛的可能应用。其他发现包括通过冷冻电子显微镜进行的结构确定和蛋白质设计验证。