A series of highly active and ortho-position selective catalysts based on (α-Fe₂O₃)_1-x(V₂O₅)_x catalysts were proposed for the C-methylation of phenol with methanol. The (α-Fe₂O₃)_1-x(V₂O₅)_x catalysts were synthesized by coprecipitation method of Fe and V elements and microwave drying. The chemical composition, material structure, acid-base properties, and structure-activity relationship of (α-Fe₂O₃)_1-x(V₂O₅)_x catalysts were systematically analyzed by the techniques of XRD, XPS, TEM, N₂ adsorption-desorption, Raman, UV-Vis, ESR, NH₃/CO₂-TPD and Pyridine-IR. The (α-Fe₂O₃)_1-x(V₂O₅)_x catalysts have the double advantages of high activity and high stability for the methylation of phenol due to the high BET surface area, large total pore volume, dispersive active sites and enhanced acid-base property. o-cresol and 2,6-xylenol were the main products, and nearly 100% selectivity to the ortho-position of phenol and 90% selectivity to o-cresol were obtained. Furthermore, the (α-Fe₂O₃)_1-x(V₂O₅)_x catalysts possess long lifetime over 2500 h and high activity at a weight hourly space velocity of 1.6 h⁻¹ compared with the microwave-dried α-Fe₂O₃ catalyst. The doping of vanadium improves the activity and stability of α-Fe₂O₃ catalyst, which attributes to the modification of catalyst structure, especially the improvement of acid-base centers and oxygen vacancy. Recently the (α-Fe₂O₃)_1-x(V₂O₅)_x catalysts have been stably and efficiently applied in industry for the methylation of phenol.

提出了一系列基于 (α-Fe ₂ O ₃ ) _{1- x} (V ₂ O ₅ ) _x催化剂的高活性和邻位选择性催化剂，用于苯酚与甲醇的C-甲基化。(α-Fe ₂ O ₃ ) _{1- x} (V ₂ O ₅ ) _x催化剂采用Fe和V元素共沉淀法和微波干燥法合成。(α-Fe ₂ O ₃ )的化学成分、材料结构、酸碱性质及构效关系通过XRD、XPS、TEM、N ₂吸附-解吸、拉曼、UV-Vis、ESR、NH ₃ /CO ₂ -TPD和吡啶-IR等技术系统地分析了_{1- x} (V ₂ O ₅ ) _x催化剂。(α-Fe ₂ O ₃ ) _{1- x} (V ₂ O ₅ ) _x催化剂由于BET比表面积大、总孔容大、分散活性高，对苯酚甲基化具有高活性和高稳定性的双重优点。位点和增强的酸碱性能。○主要产物为-甲酚和2,6-二甲苯酚，对苯酚的邻位选择性接近100%，对邻甲酚的选择性接近90% 。此外，与微波干燥的α-催化剂相比，(α-Fe ₂ O ₃ ) _{1- x} (V ₂ O ₅ ) _x催化剂具有超过 2500 小时的长寿命和在 1.6 小时^-1的重时空速下的高活性。Fe ₂ O ₃催化剂。钒的掺杂提高了α-Fe ₂ O ₃的活性和稳定性催化剂，这归因于催化剂结构的改变，特别是酸碱中心和氧空位的改善。近年来，(α-Fe ₂ O ₃ ) _{1- x} (V ₂ O ₅ ) _x催化剂在苯酚甲基化的工业中得到稳定有效的应用。