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Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks
Trends in Cell Biology ( IF 19.0 ) Pub Date : 2021-09-17 , DOI: 10.1016/j.tcb.2021.08.004
Dan Li 1 , Cong Liu 2
Affiliation  

Membraneless organelles (MLOs) present as a condensed metastable phase of different proteins and RNAs organized via liquid–liquid phase separation. Recent evidence suggests the extensive incorporation of molecular chaperones into the dynamic assembly of MLOs, where different chaperones coordinate to spatiotemporally maintain the protein homeostasis and avoid abnormal protein aggregation.



中文翻译:

伴侣网络对无膜细胞器的时空动态调控

无膜细胞器 (MLO) 作为通过液-液相分离组织的不同蛋白质和 RNA 的凝聚亚稳相存在。最近的证据表明,分子伴侣广泛纳入 MLO 的动态组装中,其中不同的伴侣协调以在时空上维持蛋白质稳态并避免异常的蛋白质聚集。

更新日期:2021-09-17
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