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Ischemic heart disease: Cellular and molecular immune contributions of the pericardium
The International Journal of Biochemistry & Cell Biology ( IF 4 ) Pub Date : 2021-09-17 , DOI: 10.1016/j.biocel.2021.106076
Jameson A Dundas 1 , Ali Fatehi Hassanabad 1 , Anna N Zarzycki 1 , Paul Wm Fedak 1 , Justin F Deniset 2
Affiliation  

Ischemic heart disease promotes complex inflammatory and remodeling pathways which contribute to the development of chronic heart failure. Although blood-derived and local cardiac mediators have traditionally been linked with these processes, the pericardial space has more recently been noted as alternative contributor to the injury response in the heart. The pericardial space contains fluid rich in physiologically active mediators, and immunologically active adipose tissue, which are altered during myocardial infarction. Key immune cells in the pericardial fluid and adipose tissue have been identified which act as mediators for cell recruitment and function after myocardial infarction have been identified in experimental models. Here, we provide an overview of the current understanding of the inflammatory mechanisms of the pericardial space and their role in post-myocardial infarction remodeling and the potential for the use of the pericardial space as a delivery vehicle for treatments to modulate heart healing.



中文翻译:

缺血性心脏病:心包的细胞和分子免疫作用

缺血性心脏病促进复杂的炎症和重塑途径,这些途径有助于慢性心力衰竭的发展。尽管传统上血液来源和局部心脏介质与这些过程有关,但最近人们注意到心包空间是心脏损伤反应的替代因素。心包空间含有富含生理活性介质和免疫活性脂肪组织的液体,这些物质在心肌梗塞期间会发生改变。已经鉴定了心包液和脂肪组织中的关键免疫细胞,它们在实验模型中鉴定出心肌梗塞后充当细胞募集和功能的介质。这里,

更新日期:2021-09-24
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