Comorbid drug use, often alcohol with other drugs, poses significant health and societal concerns. Methamphetamine is among the illicit drugs most often co-used with alcohol. The current review examines the animal literature for impacts of comorbid alcohol and methamphetamine exposure. We found evidence for additive or synergistic effects of combined or sequential exposure on behavior and physiology. Dopaminergic, serotonergic, and glutamatergic systems are all impacted by combined exposure to alcohol and methamphetamine and cyclooxygenase-2 activity plays an important role in their combined neurotoxic effects. Adverse consequences of comorbid exposure include altered brain development with prenatal exposure, impaired learning and memory, motor deficits, gastrotoxicity, hepatotoxicity, and augmented intake under some conditions. Given high susceptibility to drug experimentation in adolescence, studies of co-exposure during the adolescent period and of how adolescent exposure to one drug impacts later use or sensitivity to the other drug should be a priority. Further, to gain traction on prevention and treatment, additional research to identify motivational and neurobiological drivers and consequences of comorbid use is needed.

合并吸毒（通常是酒精与其他药物）会引起严重的健康和社会问题。甲基苯丙胺是最常与酒精一起使用的非法药物之一。当前的审查检查了动物文献中酒精和甲基​​苯丙胺共病暴露的影响。我们发现了组合或顺序暴露对行为和生理的累加或协同效应的证据。多巴胺能、血清素能和谷氨酸能系统都受到酒精和甲基​​苯丙胺联合暴露的影响，环氧合酶 2 活性在它们的联合神经毒性作用中起着重要作用。合并症暴露的不良后果包括大脑发育因产前暴露而改变、学习和记忆受损、运动障碍、胃毒性、肝毒性以及某些情况下的摄入量增加。鉴于青春期对药物实验的高度敏感性，应优先研究青春期的共同暴露以及青少年暴露于一种药物如何影响以后的使用或对另一种药物的敏感性。此外，为了获得预防和治疗的牵引力，需要进行额外的研究以确定动机和神经生物学驱动因素以及合并症使用的后果。