The medial temporal lobe drives semantic congruence dependent memory formation. However, the exact roles of hippocampal subfields and surrounding brain regions remain unclear. Here, we used an established paradigm and high-resolution functional magnetic resonance imaging of the medial temporal lobe together with cytoarchitectonic probability estimates in healthy humans. Behaviorally, robust congruence effects emerged in young and older adults, indicating that schema dependent learning is unimpaired during healthy aging. Within the medial temporal lobe, semantic congruence was associated with hemodynamic activity in the subiculum, CA1, CA3 and dentate gyrus, as well as the entorhinal cortex and laterobasal amygdala. Importantly, a subsequent memory analysis showed increased activity for later remembered vs. later forgotten congruent items specifically within CA3, and this subfield showed enhanced functional connectivity to the laterobasal amygdala. As such, our findings extend current models on schema dependent learning by pinpointing the functional properties of subregions within the medial temporal lobe.

内侧颞叶驱动语义一致性依赖的记忆形成。然而，海马亚区和周围大脑区域的确切作用仍不清楚。在这里，我们使用了已建立的范式和内侧颞叶的高分辨率功能磁共振成像以及健康人的细胞结构概率估计。在行为上，年轻人和老年人出现了强烈的一致性效应，表明图式依赖学习在健康老龄化期间没有受到损害。在内侧颞叶内，语义一致性与下托、CA1、CA3 和齿状回以及内嗅皮质和外侧基底杏仁核的血流动力学活动相关。重要的是，随后的记忆分析显示，后来记忆的活动增加了。后来忘记了特别是在 CA3 内的一致项目，并且该子区域显示出与外侧基底杏仁核的功能连接性增强。因此，我们的研究结果通过确定内侧颞叶内亚区域的功能特性，扩展了当前模式依赖学习的模型。