Magnesium nanoparticles have been the focus of study over the past few years because of its functionality in the body. Assessment of the impact of magnesium oxide nanoparticles (MgNPs) on eimeriosis has yet to be conducted. The goal of this study was to see how MgNPs affected the parasite Eimeria papillata infected jejunum. To induce eimeriosis, mice were infected with sporulated oocysts. For treatment, 5 mg / Kg MgNPs was used for 5 consecutive days. The infection reduced the number of intestinal goblet cells and their associated genes MUC2 and MUC4, as well as increasing oxidative damage in the jejunum. MgNPs significantly reduced the oocyst production in the feces by about 77 %. After treatment, the number of goblet cells per villus increased from 4.17% to 7.40.6%. Moreover, the MgNPs were able to upregulate the expression of MUC2 and MUC4-mRNA. MgNPs significantly increased the activity of catalase and superoxide dismutase, as well as the extent of glutathione, by day 5 after infection with the parasite. On contrary, MgNPs decreased the level of malondialdehyde and nitric oxide. The findings suggested that MgNPs could be an effective anti-eimeriosis agent due to their anti-eimerial and anti-oxidant roles, as well as the regulatory effect on the goblet cell mucin genes in the jejunum of mice.

镁纳米粒子因其在体内的功能而成为过去几年研究的焦点。尚未进行氧化镁纳米颗粒 (MgNPs) 对艾虫病影响的评估。本研究的目的是了解 MgNPs 如何影响寄生虫感染的空肠艾美球虫。为了诱导艾虫病，小鼠被孢子化的卵囊感染。对于治疗，连续 5 天使用 5 mg/Kg MgNPs。感染减少了肠杯状细胞及其相关基因MUC2和MUC4的数量，以及增加空肠的氧化损伤。MgNPs 将粪便中的卵囊产量显着降低了约 77%。处理后，每个绒毛的杯状细胞数从4.17%增加到7.40.6%。此外，MgNPs 能够上调MUC2和MUC4 -mRNA 的表达。到感染寄生虫后的第 5 天，MgNPs 显着增加了过氧化氢酶和超氧化物歧化酶的活性，以及​​谷胱甘肽的含量。相反，MgNPs 降低了丙二醛和一氧化氮的水平。研究结果表明，MgNPs 可能是一种有效的抗艾虫病剂，因为它们具有抗艾虫病和抗氧化作用，以及对小鼠空肠杯状细胞粘蛋白基因的调节作用。