Self-assembled biological structures have played a significant role in many living systems for its functionality and distinctiveness. Here, we experimentally demonstrate that the random dynamic behavior of strong light–matter interactions in complex biological structures can provide hidden information on optical coupling in a network. The concept of biophotonic lasing network is therefore introduced, where a self-assembled human amyloid fibril network was confined in a Fabry–Perot optical cavity. Distinctive lasing patterns were discovered from self-assembled amyloids with different structural dimensions (0D, 1D, 2D, and 3D) confined in a microcavity. Network laser emission exhibiting evidence of light coupling at different wavelengths and locations was spectrally resolved. Dynamic changes of lasing patterns can therefore be interpreted into a graph to reveal the optical correlation in biophotonic networks. Our findings indicate that each graph represents the highly unclonable features of a self-assembled network which can sensitively respond to environmental stimulus. This study offers the potential for studying dynamic biological networks through amplified interactions, shedding light on the development of biologically controlled photonic devices, biosensing, and information encryption.

中文翻译：

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微腔中由淀粉样原纤维驱动的自组装生物光子激光网络

自组装生物结构因其功能性和独特性在许多生命系统中发挥了重要作用。在这里，我们通过实验证明复杂生物结构中强光-物质相互作用的随机动态行为可以提供关于网络中光耦合的隐藏信息。因此引入了生物光子激光网络的概念，其中自组装的人类淀粉样原纤维网络被限制在 Fabry-Perot 光学腔中。从限制在微腔中的具有不同结构尺寸（0D、1D、2D 和 3D）的自组装淀粉样蛋白中发现了独特的激光模式。网络激光发射在不同波长和位置表现出光耦合的证据被光谱解析。因此，可以将激光模式的动态变化解释为图表，以揭示生物光子网络中的光学相关性。我们的研究结果表明，每个图都代表了一个自组装网络的高度不可克隆的特征，它可以对环境刺激做出敏感的反应。这项研究为通过放大的相互作用研究动态生物网络提供了潜力，揭示了生物控制光子设备、生物传感和信息加密的发展。