Scientific Reports ( IF 4.6 ) Pub Date : 2021-09-17 , DOI: 10.1038/s41598-021-97539-2 Catherine C Applegate 1 , Matthew R Lowerison 2, 3 , Emma Hambley 1, 4 , Pengfei Song 2, 3, 5 , Matthew A Wallig 1, 6 , John W Erdman 1, 2, 5, 7
Prostate cancer (PCa) remains the second most diagnosed cancer worldwide. Higher body weight is associated with chronic inflammation, increased angiogenesis, and treatment-resistant tumor phenotypes. Dietary tomato reduces PCa risk, which may be due to tomato inhibition of angiogenesis and disruption of androgen signaling. This pilot study investigated the interplay between tomato powder (TP), incorporated into control (CON) and obesogenic (OB) diets, and PCa tumor growth and blood perfusion over time in a transgenic model of PCa (TRAMP). Ultrasound microvessel imaging (UMI) results showed good agreement with gold-standard immunohistochemistry quantification of endothelial cell density, indicating that this technique can be applied to non-invasively monitor tumor blood perfusion in vivo. Greater body weight was positively associated with tumor growth. We also found that TP significantly inhibited prostate tumor angiogenesis but that this inhibition differentially affected measured outcomes depending on CON or OB diets. TP led to reduced tumor growth, intratumoral inflammation, and intratumoral androgen-regulated gene expression (srd5a1, srd5a2) when incorporated with the CON diet but greater tumor growth and intratumoral gene expression when incorporated with the OB diet. Results from this study show that protective benefits from dietary tomato are lost, or may become deleterious, when combined with a Western-style diet.
中文翻译:
膳食番茄可抑制 TRAMP 前列腺癌的血管生成,但在这项试点研究中西式饮食并不能起到保护作用
前列腺癌 (PCa) 仍然是全球第二大诊断癌症。较高的体重与慢性炎症、血管生成增加和耐药性肿瘤表型有关。饮食番茄可降低前列腺癌风险,这可能是由于番茄抑制血管生成和破坏雄激素信号传导所致。这项初步研究调查了在 PCa 转基因模型 (TRAMP) 中掺入对照 (CON) 和致肥 (OB) 饮食的番茄粉 (TP) 与 PCa 肿瘤生长和血液灌注随时间的相互作用。超声微血管成像(UMI)结果与内皮细胞密度的金标准免疫组织化学定量结果良好吻合,表明该技术可应用于体内无创监测肿瘤血液灌注。体重增加与肿瘤生长呈正相关。我们还发现 TP 显着抑制前列腺肿瘤血管生成,但这种抑制对测量结果的影响不同,具体取决于 CON 或 OB 饮食。当与CON饮食结合时,TP导致肿瘤生长、瘤内炎症和瘤内雄激素调节基因表达(srd5a1、srd5a2)减少,但当与OB饮食结合时,TP导致肿瘤生长和瘤内基因表达增加。这项研究的结果表明,当与西式饮食结合时,膳食番茄的保护作用就会消失,或者可能变得有害。