The purpose of the present study was to evaluate layered of satranidazole powder using natural polysaccharides as coating materials for colon targeting that were inexpensive and natural with a non-toxic nature using a composite response design of 3 levels and 2 factors for each of the four responses in the quadratic model. The independent variables were the ratio of coating consistency % (X1) and coating level % (X2) in the pellet. The dependent factors were % release of drug at 2 h. (Y1), % release of drug at 6 h. (Y2), % release of drug difference in presence & absence of colonic enzyme (Y3) and mean dissolution time (Y4). The various models were fitted for the responses with an explanation of suitable statistical methods. Variance analysis and different factor levels of responses were constructed by response surface plots. Satranidazole pellets were efficiently prepared by the variable amount of ingredients that showed compatibility with possible pellet characterization and drug dissolution profiles to optimize the formulation. The strategy of response surface can be a successful tool for improving the prepared satranidazole pellets which can be an appropriate replacement of regular one.

中文翻译：

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响应面法优化制备的沙硝唑粉末层状微丸

本研究的目的是评估使用天然多糖作为结肠靶向包衣材料的沙硝唑层状粉末，其价格低廉、天然且无毒，对四种反应中的每一种使用 3 个水平和 2 个因子的复合反应设计。在二次模型中。自变量是颗粒中包衣稠度 % (X1) 和包衣水平 % (X2) 的比率。相关因素是药物在 2 小时时的释放百分比。(Y1)，药物在 6 小时时的释放百分比。(Y2)，存在和不存在结肠酶 (Y3) 和平均溶解时间 (Y4) 时的药物释放百分比差异。为响应拟合了各种模型，并解释了合适的统计方法。通过响应曲面图构建响应的方差分析和不同的因子水平。沙曲硝唑微丸是通过可变数量的成分有效制备的，这些成分显示出与可能的微丸特性和药物溶出曲线的相容性，以优化配方。响应面策略可以成为改进制备的沙硝唑微丸的成功工具，可以适当替代常规微丸。