The importance of clinicolaboratory characteristics of COVID-19 made us report our findings in the Alborz province according to the latest National Guideline for the diagnosis and treatment of COVID-19 in outpatients and inpatients (trial five versions, 25 March 2020) of Iran by emphasizing rRT-PCR results, clinical features, comorbidities, and other laboratory findings in patients according to the severity of the disease. In this study, 202 patients were included, primarily of whom 164 had fulfilled the inclusion criteria. This cross-sectional, two-center study that involved 164 symptomatic adults hospitalized with the diagnosis of COVID-19 between March 5 and April 5, 2020, was performed to analyze the frequency of rRT-PCR results, distribution of comorbidities, and initial clinicolaboratory data in severe and non-severe cases, comparing the compatibility of two methods for categorizing the severity of the disease. According to our findings, 111 patients were rRT-PCR positive (67.6%), and 53 were rRT-PCR negative (32.4%), indicating no significant difference between severity groups that were not related to the date of symptoms' onset before admission. Based on the National Guideline, among vital signs and symptoms, mean oxygen saturation and frequency of nausea showed a significant difference between the two groups (P < 0.05); however, no significant difference was observed in comorbidities. In CURB-65 groups, among vital signs and comorbidities, mean oxygen saturation, diabetes, hypertension (HTN), hyperlipidemia, chronic heart disease (CHD), and asthma showed a significant difference between the two groups (P < 0.05), but no significant difference was seen in symptoms. In this study, rRT-PCR results of hospitalized patients with COVID-19 were not related to severity categories. From initial clinical characteristics, decreased oxygen saturation appears to be a more common abnormality in severe and non-severe categories. National Guideline indices seem to be more comprehensive to categorize patients in severity groups than CURB-65, and there was compatibility just in non-severe groups of National Guideline and CURB-65 categories.

中文翻译：

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基于 CURB-65 和 WHO 严重程度指数的重症和非重症 COVID19 患者的临床和实验室检查结果以及 PCR 结果

COVID-19 临床实验室特征的重要性促使我们根据伊朗最新的国家门诊和住院患者 COVID-19 诊断和治疗指南（试行五个版本，2020 年 3 月 25 日）报告我们在厄尔布尔士省的发现，强调根据疾病的严重程度，对患者进行 rRT-PCR 结果、临床特征、合并症和其他实验室检查结果。在这项研究中，纳入了 202 名患者，其中 164 名主要满足纳入标准。这项横断面、两中心研究涉及 2020 年 3 月 5 日至 4 月 5 日期间因诊断为 COVID-19 而住院的 164 名有症状的成年人，旨在分析 rRT-PCR 结果的频率、合并症的分布以及初始临床实验室严重和非严重病例的数据，比较两种疾病严重程度分类方法的兼容性。根据我们的研究结果，111 名患者 rRT-PCR 阳性（67.6%），53 名患者 rRT-PCR 阴性（32.4%），表明与入院前症状出现日期无关的严重程度组之间没有显着差异。根据国家指南，生命体征和症状中，平均氧饱和度和恶心频率两组间差异有统计学意义（P < 0.05）；然而，在合并症方面没有观察到显着差异。在CURB-65组中，在生命体征和合并症中，平均氧饱和度、糖尿病、高血压（HTN）、高脂血症、慢性心脏病（CHD）和哮喘在两组之间显示出显着性差异（P < 0.05），但没有差异症状有显着差异。在这项研究中，住院的 COVID-19 患者的 rRT-PCR 结果与严重程度类别无关。从最初的临床特征来看，氧饱和度降低似乎是严重和非严重类别中更常见的异常。国家指南指数似乎比 CURB-65 更全面地对严重程度组的患者进行分类，并且仅在国家指南和 CURB-65 类别的非严重组中具有兼容性。