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Association Between Anxiety and Cognitive Decline Over 12 Years in a Population-Based Cohort
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-16 , DOI: 10.3233/jad-210282
Scherazad Kootar 1, 2 , Md Hamidul Huque 1, 2 , Richard Arthur 3 , Moyra Mortby 1, 2 , Kaarin J Anstey 1, 2, 3
Affiliation  

Background:Findings on the associations between anxiety and cognitive decline are mixed and often confounded. Objective:We studied whether anxiety symptoms were associated with the risk of cognitive decline after adequate adjustment of confounding factors. Methods:Our study consists of 2,551 community-dwelling older adults recruited between the ages of 60–64 years and followed up for 12 years in the PATH Through Life cohort study. Anxiety symptoms were measured using the Goldberg Anxiety Scale (GAS; range 0–9). General cognitive function, episodic memory, working memory, verbal intelligence, processing speed, and psychomotor speed were measured. Multilevel analyses were carried out to investigate the association between anxiety symptoms and cognitive decline over 12 years, taking into account confounding variables. Results:We did not find a significant association between baseline anxiety symptoms and cognitive decline over 12 years. Although some associations between anxiety symptoms with psychomotor speed (β= –0.04, 99%CI: –0.08, 0.00) and processing speed (β= –0.27, 99%CI: –0.48, –0.07) were found, these were attenuated after adjusting for depression. We also did not find an association between cumulative anxiety and decline in cognitive performance. Conclusion:In this sample of cognitively healthy men and women aged 60 years and above, anxiety symptoms were not associated with the risk of cognitive decline. Long follow-up study time, appropriate selection of confounding factors, and estimating the effect of cumulative anxiety are important to establish the association between anxiety and cognitive symptoms.

中文翻译:

在基于人群的队列中,焦虑与认知能力下降 12 年之间的关联

背景:关于焦虑和认知能力下降之间关联的研究结果喜忧参半,而且经常混淆。目的:我们研究了在充分调整混杂因素后焦虑症状是否与认知能力下降的风险相关。方法:我们的研究由 2,551 名年龄在 60-64 岁之间的社区老年人组成,并在 PATH 终生队列研究中随访了 12 年。使用戈德堡焦虑量表(GAS;范围 0-9)测量焦虑症状。测量了一般认知功能、情景记忆、工作记忆、语言智力、处理速度和精神运动速度。考虑到混杂变量,进行了多层次分析以调查焦虑症状与 12 年认知能力下降之间的关联。结果:12 年来,我们没有发现基线焦虑症状与认知能力下降之间存在显着关联。尽管发现焦虑症状与精神运动速度 (β= –0.04, 99%CI: –0.08, 0.00) 和处理速度 (β= –0.27, 99%CI: –0.48, –0.07) 之间存在一些关联,但在调整抑郁症。我们也没有发现累积焦虑与认知能力下降之间存在关联。结论:在这个 60 岁及以上认知健康的男性和女性样本中,焦虑症状与认知能力下降的风险无关。Long follow-up study time, appropriate selection of confounding factors, and estimating the effect of cumulative anxiety are important to establish the association between anxiety and cognitive symptoms.
更新日期:2021-09-17
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