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Combining Multimodal Behavioral Data of Gait, Speech, and Drawing for Classification of Alzheimer’s Disease and Mild Cognitive Impairment
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-16 , DOI: 10.3233/jad-210684
Yasunori Yamada 1 , Kaoru Shinkawa 1 , Masatomo Kobayashi 1 , Vittorio Caggiano 2 , Miyuki Nemoto 3 , Kiyotaka Nemoto 4 , Tetsuaki Arai 4
Affiliation  

Background:Gait, speech, and drawing behaviors have been shown to be sensitive to the diagnosis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). However, previous studies focused on only analyzing individual behavioral modalities, although these studies suggested that each of thesemodalities may capture different profiles of cognitive impairments associated with AD. Objective:We aimed to investigate if combining behavioral data of gait, speech, and drawing can improve classification performance compared with the use of individual modality and if each of these behavioral data can be associated with different cognitive and clinical measures for the diagnosis of AD and MCI. Methods:Behavioral data of gait, speech, and drawing were acquired from 118 AD, MCI, and cognitively normal (CN) participants. Results:Combining all three behavioral modalities achieved 93.0%accuracy for classifying AD, MCI, and CN, and only 81.9%when using the best individual behavioral modality. Each of these behavioral modalities was statistically significantly associated with different cognitive and clinical measures for diagnosing AD and MCI. Conclusion:Our findings indicate that these behaviors provide different and complementary information about cognitive impairments such that classification of AD and MCI is superior to using either in isolation.

中文翻译:

结合步态、言语和绘图的多模态行为数据对阿尔茨海默病和轻度认知障碍进行分类

背景:步态、言语和绘画行为已被证明对阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的诊断很敏感。然而,之前的研究只关注分析个体行为模式,尽管这些研究表明这些模式中的每一种都可能捕捉到与 AD 相关的认知障碍的不同概况。目的:我们旨在调查与使用个体模式相比,结合步态、言语和绘画的行为数据是否可以提高分类性能,以及这些行为数据中的每一个是否可以与不同的认知和临床措施相关联,以诊断 AD 和MCI。方法:从 118 名 AD、MCI 和认知正常 (CN) 参与者获取步态、言语和绘画的行为数据。结果:
更新日期:2021-09-17
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