White Matter but not Gray Matter Volumes are Associated with Cognition in Community-Dwelling Chinese Populations,Journal of Alzheimer’s Disease

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White Matter but not Gray Matter Volumes are Associated with Cognition in Community-Dwelling Chinese Populations
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-16 , DOI: 10.3233/jad-210367
Quan Wang ₁ , Ning Su ₁ , Jin Huang ₂ , Xinyu Liang ₃ , Jing Yuan ₁ , Ming Yao ₁ , Li-Xin Zhou ₁ , Zheng-Yu Jin ₄ , Shu-Yang Zhang ₅ , Li-Ying Cui ₁ , Gaolang Gong ₃ , Feng Tian ₂ , Yi-Cheng Zhu ₁ , Jun Ni ₁

Affiliation

Background:Few studies have investigated the association between cognition and brain volume associated with cerebral small vessel disease (CSVD). Objective:We investigated the association between cognition and brain volume and neuroimaging markers of CSVD in a community-dwelling population. Methods:Participants (n = 993, age≥35 years) from the community-based Shunyi Study were included to investigate the association between neuroimaging markers and cognition cross-sectionally. Magnetic resonance imaging markers included brain volume measurements of the total cerebrum, white matter, gray matter, and CSVD imaging markers. Cognitive performance was assessed using neuropsychological tests of the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Fuld Object Memory, digit span, Trail Making Test (TMT)-A, and TMT-B. Results:For brain volume measurement, subcortical white matter fraction was positively associated with MMSE score (β= 0.034, p = 0.0062) and MoCA score (β= 0.034, p = 0.0174), and negatively associated with TMT-A and TMT-B completion time (β= –2.319, p = 0.0002; β= –2.827, p = 0.0073, respectively). For evaluation of CSVD imaging markers, the presence of lacunes was positively associated with TMT-B completion time (β= 17.241, p = 0.0028). Conclusion:In community-dwelling populations, reduced white matter volumes, as a consequence of aging and vascular damage, are associated with worse global cognition and executive function. Our findings provide potential insights into the correlation between cognition and CSVD-associated subcortical white matter injury.

更新日期：2021-09-17

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