People with diabetes (PWD) have an increased risk of developing influenza-related complications, including pneumonia, abnormal glycemic events, and hospitalization. Annual influenza vaccination is recommended for PWD, but vaccination rates are suboptimal. The study aimed to increase influenza vaccination rate in people with self-reported diabetes. This study was a prospective, 1:1 randomized controlled trial of a 6-month Digital Diabetes Intervention in U.S. adults with diabetes. The intervention group received monthly messages through an online health platform. The control group received no intervention. Difference in self-reported vaccination rates was tested using multivariable logistic regression controlling for demographics and comorbidities. The study was registered at clinicaltrials.gov: NCT03870997. A total of 10,429 participants reported influenza vaccination status (5158 intervention, mean age (±SD) = 46.8 (11.1), 78.5% female; 5271 control, Mean age (±SD) = 46.7 (11.2), 79.4% female). After a 6-month intervention, 64.2% of the intervention arm reported influenza vaccination, vers us 61.1% in the control arm (diff = 3.1, RR = 1.05, 95% CI [1.02, 1.08], p = 0.0013, number needed to treat = 33 to obtain 1 additional vaccination). Completion of one or more intervention messages was associated with up to an 8% increase in vaccination rate (OR 1.27, 95% CI [1.17, 1.38], p < 0.0001). The intervention improved influenza vaccination rates in PWD, suggesting that leveraging new technology to deliver knowledge and information can improve influenza vaccination rates in high-risk populations to reduce public health burden of influenza. Rapid cycle innovation could maximize the effects of these digital interventions in the future with other populations and vaccines.

糖尿病患者 (PWD) 发生流感相关并发症的风险增加，包括肺炎、异常血糖事件和住院治疗。建议残障人士每年接种流感疫苗，但疫苗接种率并不理想。该研究旨在提高自我报告的糖尿病患者的流感疫苗接种率。本研究是一项针对美国成人糖尿病患者进行的为期 6 个月的数字糖尿病干预的前瞻性 1:1 随机对照试验。干预组通过在线健康平台每月收到消息。对照组不接受干预。使用控制人口统计学和合并症的多变量逻辑回归测试了自我报告的疫苗接种率的差异。该研究在clinicaltrials.gov注册：NCT03870997。一共10个，429 名参与者报告了流感疫苗接种状态（5158 名干预，平均年龄 (±SD) = 46.8 (11.1)，78.5% 女性；5271 名对照组，平均年龄 (±SD) = 46.7 (11.2)，79.4% 女性）。6 个月的干预后，64.2% 的干预组报告接种了流感疫苗，而对照组为 61.1%（差异 = 3.1，RR = 1.05，95% CI [1.02, 1.08]，p  = 0.0013，需要治疗的数量 = 33 以获得 1 次额外的疫苗接种）。完成一个或多个干预信息与疫苗接种率增加高达 8% 相关（OR 1.27, 95% CI [1.17, 1.38], p  < 0.0001）。该干预措施提高了残疾人的流感疫苗接种率，表明利用新技术传递知识和信息可以提高高危人群的流感疫苗接种率，从而减轻流感的公共卫生负担。快速循环创新可以最大限度地提高这些数字干预在未来对其他人群和疫苗的影响。