Highlighting the relationship between obsessive–compulsive disorder (OCD) and tic disorder (TD), two highly disabling, comorbid, and difficult-to-treat conditions, Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) acknowledged a new “tic-related” specifier for OCD, ie, obsessive–compulsive tic-related disorder (OCTD). As patients with OCTD may frequently show poor treatment response, the aim of this multicenter study was to investigate rates and clinical correlates of response, remission, and treatment resistance in a large multicenter sample of OCD patients with versus without tics.

A sample of 398 patients with a DSM-5 diagnosis of OCD with and without comorbid TD was assessed from 10 different psychiatric departments across Italy. For the purpose of the study, treatment response profiles in the whole sample were analyzed comparing the rates of response, remission, and treatment-resistance as well as related clinical features. Multivariate logistic regressions were performed to identify possible factors associated with treatment response.

The remission group was associated with later ages of onset of TD and OCD. Moreover, significantly higher rates of psychiatric comorbidities, TD, and lifetime suicidal ideation and attempts emerged in the treatment-resistant group, with larger degrees of perceived worsened quality of life and family involvement.

Although remission was associated with later ages of OCD and TD onset, specific clinical factors, such as early onset and presence of psychiatric comorbidities and concomitant TD, predicted a worse treatment response with a significant impairment in quality of life for both patients and their caregivers, suggesting a worse profile of treatment response for patients with OCTD.

强调强迫症 (OCD) 和抽动障碍 (TD) 之间的关系，这两种高度致残、共病且难以治疗的疾病，《精神疾病诊断和统计手册》第五版 (DSM-5) 承认了一种新的强迫症的“抽动相关”说明符，即强迫性抽动相关障碍 (OCTD)。由于 OCTD 患者可能经常表现出较差的治疗反应，因此这项多中心研究的目的是在有抽动与无抽动的 OCD 患者的大型多中心样本中调查反应、缓解和治疗抵抗的发生率和临床相关性。

对来自意大利 10 个不同精神病科的 398 名 DSM-5 诊断为强迫症伴或不伴有 TD 的患者样本进行了评估。为了研究的目的，分析了整个样本中的治疗反应概况，比较了反应率、缓解率和治疗耐药率以及相关的临床特征。进行多变量逻辑回归以确定与治疗反应相关的可能因素。

缓解组与较晚的 TD 和 OCD 发病年龄相关。此外，在治疗抵抗组中出现了显着更高的精神疾病、TD 和终生自杀意念和企图的发生率，并且更大程度地感知到生活质量和家庭参与的恶化。

尽管缓解与强迫症和 TD 发病年龄较晚有关，但特定的临床因素，例如早发和存在精神疾病以及伴随的 TD，预示着治疗反应较差，患者及其护理人员的生活质量显着受损，表明 OCTD 患者的治疗反应更差。