Vaccines against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are critical weapons to control the spread of the deadly Coronavirus 2019(COVId-19) virus worldwide. Although these vaccines are generally safe, their widespread use has produced reports of rare complications, including vaccine-induced immune thrombotic thrombocytopenia (VIITT), particularly in connection with ChAdOx1 nCov-19. We have identified three cases of sickle cell disease (SCD) experiencing a severe vaso-occlusive crisis (VOC) shortly after the vaccine. Despite being stable for a long time, they had fever with tachycardia, along with a significant rise in WBC, liver enzymes, particularly alkaline phosphate, with a remarkable drop in hemoglobin, and platelets and one of them had probably a fatal TTP like syndrome. Given these findings, physicians and patients should exercise caution when taking this type of vaccine and be aware of these safety concerns.

中文翻译：

---

ChAdOx1 nCov-19 疫苗在镰状细胞病患者中的安全警告。

针对急性呼吸系统综合症冠状病毒 2 (SARS-CoV2) 的疫苗是控制致命的 2019 冠状病毒 (COVId-19) 病毒在全球范围内传播的关键武器。尽管这些疫苗通常是安全的，但它们的广泛使用已经产生了罕见并发症的报告，包括疫苗引起的免疫血栓性血小板减少症 (VIITT)，特别是与 ChAdOx1 nCov-19 相关的并发症。我们已经确定了三例镰状细胞病 (SCD) 在接种疫苗后不久出现严重血管闭塞危象 (VOC) 的病例。尽管长期稳定，但他们发烧并伴有心动过速，白细胞显着升高，肝酶，尤其是碱性磷酸盐，血红蛋白和血小板显着下降，其中一个人可能患有致命的 TTP 样综合征。鉴于这些发现，