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Neuronal Avalanches Across the Rat Somatosensory Barrel Cortex and the Effect of Single Whisker Stimulation.
Frontiers in Systems Neuroscience ( IF 3 ) Pub Date : 2021-08-30 , DOI: 10.3389/fnsys.2021.709677
Benedetta Mariani 1, 2 , Giorgio Nicoletti 1 , Marta Bisio 2, 3 , Marta Maschietto 3 , Roberto Oboe 4 , Alessandro Leparulo 3 , Samir Suweis 1, 2 , Stefano Vassanelli 2, 3
Affiliation  

Since its first experimental signatures, the so called "critical brain hypothesis" has been extensively studied. Yet, its actual foundations remain elusive. According to a widely accepted teleological reasoning, the brain would be poised to a critical state to optimize the mapping of the noisy and ever changing real-world inputs, thus suggesting that primary sensory cortical areas should be critical. We investigated whether a single barrel column of the somatosensory cortex of the anesthetized rat displays a critical behavior. Neuronal avalanches were recorded across all cortical layers in terms of both multi-unit activities and population local field potentials, and their behavior during spontaneous activity compared to the one evoked by a controlled single whisker deflection. By applying a maximum likelihood statistical method based on timeseries undersampling to fit the avalanches distributions, we show that neuronal avalanches are power law distributed for both multi-unit activities and local field potentials during spontaneous activity, with exponents that are spread along a scaling line. Instead, after the tactile stimulus, activity switches to a transient across-layers synchronization mode that appears to dominate the cortical representation of the single sensory input.

中文翻译:

穿过大鼠体感桶状皮层的神经元雪崩和单晶须刺激的影响。

自从它的第一个实验签名以来,所谓的“关键大脑假设”已经被广泛研究。然而,它的实际基础仍然难以捉摸。根据广泛接受的目的论推理,大脑将处于临界状态以优化嘈杂且不断变化的现实世界输入的映射,因此表明初级感觉皮层区域应该是关键的。我们调查了麻醉大鼠的躯体感觉皮层的单个桶柱是否显示出关键行为。在多单元活动和种群局部场电位方面,记录了所有皮质层的神经元雪崩,以及与受控单晶须偏转引起的行为相比,它们在自发活动期间的行为。通过应用基于时间序列欠采样的最大似然统计方法来拟合雪崩分布,我们表明神经元雪崩是自发活动期间多单元活动和局部场电位的幂律分布,其指数沿标度线分布。相反,在触觉刺激之后,活动切换到瞬态跨层同步模式,该模式似乎主导了单个感官输入的皮层表示。
更新日期:2021-08-30
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