Kallikrein 7 (KLK7) is a secreted serine protease with chymotrypsic protease activity. Abnormally high expression of KLK7 is closely related to the occurrence and development of various types of cancer. Therefore, KLK7 has been identified as a potential target for cancer drug development design in recent years. KLK7 mediates various biological and pathological processes in tumorigenesis, including cell proliferation, migration, invasion, angiogenesis, and cell metabolism, by hydrolyzing a series of substrates such as membrane proteins, extracellular matrix proteins, and cytokines. This review mainly introduces the downstream cell signaling pathways involved in the activation of KLK7 and its substrate-related proteins. This review will not only help us to better understand the mechanisms of KLK7 in regulating biological and pathological processes of cancer cells but also lay a solid foundation for the design of inhibitors targeting KLK7.

中文翻译：

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激肽释放酶 7 在肿瘤发生中的作用。

激肽释放酶 7 (KLK7) 是一种分泌型丝氨酸蛋白酶，具有糜蛋白酶活性。KLK7的异常高表达与各类癌症的发生发展密切相关。因此，近年来KLK7已被确定为癌症药物开发设计的潜在靶点。KLK7通过水解膜蛋白、细胞外基质蛋白和细胞因子等一系列底物，介导肿瘤发生过程中的各种生物学和病理过程，包括细胞增殖、迁移、侵袭、血管生成和细胞代谢。本综述主要介绍KLK7及其底物相关蛋白激活所涉及的下游细胞信号通路。