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Fetoscopic laser ablation therapy in monochorionic diamniotic twin pregnancies with twin-to-twin transfusion syndrome treated at a single centre over 10 years: a retrospective study
Journal of Perinatal Medicine ( IF 2.4 ) Pub Date : 2021-09-15 , DOI: 10.1515/jpm-2021-0058
Anna Fichera 1, 2 , Vita Valentina Azzaretto 1 , Nicola Fratelli 1 , Sara Mancino 1 , Daria Marella 1 , Beatrice Negri 1 , Adriana Valcamonico 1 , Cristina Zanardini 1 , Tiziana Frusca 1, 3 , Enrico Sartori 1, 2 , Federico Prefumo 1, 2
Affiliation  

Objectives To review experience with fetoscopic laser ablation of placental anastomoses to treat monochorionic diamniotic (MCDA) twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) in a single centre over a ten-year period. Methods A retrospective study on 142 MCDA twin pregnancies complicates by TTTS treated with equatorial laser ablation of placental anastomoses (2008–2018). Solomon technique was also applied after 2013. Survival rates, neonatal outcome, intraoperative and post-laser complications were recorded, and prognostic factors analysed. Results A total of 133 cases were included in the final analysis; 41 patients were at stage II (30.8%), 73 were at stage III (62.9%), while only 12 (9%) at stage I and two patients (1.7%) at stage IV. Solomon technique was applied in 39 cases (29.3%). Survival of both twins was 51.1% (68/133), of a single twin 20.3% (27/133), and of at least one 71.5% (95/133), with an overall survival of 61.3% (163/266). TAPS and recurrent TTTS occurred in 8 (6%) and 15 (11.3%) patients. Survival of both fetuses increased over time (44.6 vs. 57.3%). A posterior placenta (p<0.003) and the use of the Solomon technique (p<0.02) were more frequent in cases with survival of both fetuses, while TTTS recurrence was significantly associated to the loss of one or two fetuses (p<0.01). Such associations were confirmed at logistic regression analysis. Conclusions Survival of both twins can improve over time and seems to be favourably associated with a placenta in the posterior location and the use of the Solomon technique.

中文翻译:

单绒毛膜双羊膜双胎妊娠合并双胎输血综合征的胎儿镜激光消融治疗在单中心治疗超过 10 年:一项回顾性研究

目的 回顾过去 10 年在单一中心使用胎儿镜激光消融胎盘吻合术治疗单绒毛膜双羊膜 (MCDA) 双胎妊娠合并双胎输血综合征 (TTTS) 的经验。方法回顾性研究142例MCDA双胎妊娠合并TTTS,赤道激光消融胎盘吻合术(2008-2018)。2013年之后也应用了所罗门技术。记录了存活率、新生儿结局、术中和激光后并发症,并分析了预后因素。结果最终纳入133例;41 名患者处于 II 期(30.8%),73 名患者处于 III 期(62.9%),而只有 12 名患者(9%)处于 I 期,2 名患者(1.7%)处于 IV 期。39例(29.3%)应用所罗门技术。两对双胞胎的存活率为 51 岁。1% (68/133),单双胞胎 20.3% (27/133),至少一个 71.5% (95/133),总生存率为 61.3% (163/266)。8 名 (6%) 和 15 名 (11.3%) 患者发生 TAPS 和复发性 TTTS。随着时间的推移,两个胎儿的存活率都有所提高(44.6% 对 57.3%)。后胎盘 (p<0.003) 和所罗门技术 (p<0.02) 的使用在两个胎儿存活的情况下更为常见,而 TTTS 复发与一个或两个胎儿的丢失显着相关 (p<0.01) . 这种关联在逻辑回归分析中得到证实。结论随着时间的推移,双胞胎的存活率可以提高,并且似乎与后部位置的胎盘和所罗门技术的使用有利相关。8 名 (6%) 和 15 名 (11.3%) 患者发生 TAPS 和复发性 TTTS。随着时间的推移,两个胎儿的存活率都有所提高(44.6% 对 57.3%)。后胎盘 (p<0.003) 和所罗门技术 (p<0.02) 的使用在两个胎儿存活的情况下更为常见,而 TTTS 复发与一个或两个胎儿的丢失显着相关 (p<0.01) . 这种关联在逻辑回归分析中得到证实。结论随着时间的推移,双胞胎的存活率可以提高,并且似乎与后部位置的胎盘和所罗门技术的使用有利相关。8 名 (6%) 和 15 名 (11.3%) 患者发生 TAPS 和复发性 TTTS。随着时间的推移,两个胎儿的存活率都有所提高(44.6% 对 57.3%)。后胎盘 (p<0.003) 和所罗门技术 (p<0.02) 的使用在两个胎儿存活的情况下更为常见,而 TTTS 复发与一个或两个胎儿的丢失显着相关 (p<0.01) . 这种关联在逻辑回归分析中得到证实。结论随着时间的推移,双胞胎的存活率可以提高,并且似乎与后部位置的胎盘和所罗门技术的使用有利相关。02)在两个胎儿都存活的情况下更常见,而 TTTS 复发与一个或两个胎儿的丢失显着相关(p<0.01)。这种关联在逻辑回归分析中得到证实。结论随着时间的推移,双胞胎的存活率可以提高,并且似乎与后部位置的胎盘和所罗门技术的使用有利相关。02)在两个胎儿都存活的情况下更常见,而 TTTS 复发与一个或两个胎儿的丢失显着相关(p<0.01)。这种关联在逻辑回归分析中得到证实。结论随着时间的推移,双胞胎的存活率可以提高,并且似乎与后部位置的胎盘和所罗门技术的使用有利相关。
更新日期:2021-09-15
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