To the Editor We read with great interest the article by Marshall-Goebel et al.¹ We are grateful to the authors for sharing their valuable data with the scientific community and appreciate the opportunity to comment.

The authors sought to determine if there is an association between quantitative changes in intracranial compartment volumes and peripapillary total retinal thickness (TRT), a quantitative assessment of optic disc edema (ODE), after spaceflight. They reported a weak positive association between increases in TRT and lateral ventricle volume after spaceflight. They concluded that while weightlessness-induced fluid redistribution during spaceflight may be a common stressor to the brain and retina, the development of ODE appears to be uncoupled with changes occurring in the intracranial compartment, and that alterations in cerebrospinal fluid (CSF) distribution that likely underlie brain structural changes are not the main cause of ODE in astronauts.

致编辑我们怀着极大的兴趣阅读了 Marshall-Goebel 等人的文章。¹我们感谢作者与科学界分享他们宝贵的数据，并感谢有机会发表评论。

作者试图确定太空飞行后颅内隔室容积的定量变化与视盘水肿 (ODE) 的定量评估 (TRT) 之间是否存在关联。他们报告说，太空飞行后 TRT 的增加与侧脑室容积之间存在弱正相关。他们得出的结论是，虽然太空飞行期间失重引起的体液重新分布可能是大脑和视网膜的常见压力源，但 ODE 的发展似乎与颅内隔室发生的变化无关，并且脑脊液 (CSF) 分布的改变可能大脑结构变化的基础并不是宇航员 ODE 的主要原因。