In order to scientifically elucidate the difference in the dissolution characteristics of crystalline atorvastatin calcium (ATCH) and the amorphous ATC solids (ATC30 and ATC120) obtained by the grinding for 30 and 120 min, X-ray powder diffractometry (XRD), infrared (IR) spectroscopy, near-infrared (NIR) spectroscopy, terahertz (THz) spectroscopy and thermal analysis were measured, and compared with the result of dissolution kinetics analysis. ATCH showed characteristic crystalline XRD pattern, but ATC30 and ATC120 showed no XRD peak profiles, meaning that those completely transformed into the amorphous solids. ATCH, ATC30 and ATC120 showed also individual characteristic IR and NIR spectra, respectively. ATCH contained 3 mol of crystal water, but ATC30 and ATC120 contained weakly binding adsorbed water in the amorphous solids, respectively. The result of the dissolution kinetic analysis based on the dissolution model including the phase transition showed that the dissolution behaviors of ATCH, ATC30 and ATC120 were significantly different, respectively, reflecting their intermolecular interaction in the solids. THz was able to indicate a difference between the chemical structure of amorphous solids ATC30 and ATC120, which were not able to discriminate by the XRD.

为了科学地阐明结晶阿托伐他汀钙（ATCH）与研磨30和120分钟得到的无定形ATC固体（ATC30和ATC120）溶解特性的差异，X射线粉末衍射（XRD）、红外（IR） ) 光谱、近红外 (NIR) 光谱、太赫兹 (THz) 光谱和热分析，并与溶解动力学分析的结果进行比较。ATCH 显示出特征结晶 XRD 图案，但 ATC30 和 ATC120 没有显示 XRD 峰轮廓，这意味着它们完全转化为无定形固体。ATCH、ATC30 和 ATC120 还分别显示了各自的特征 IR 和 NIR 光谱。ATCH 含有 3 mol 结晶水，但 ATC30 和 ATC120 分别在无定形固体中含有弱结合吸附水。基于包含相变的溶出模型的溶出动力学分析结果表明，ATCH、ATC30和ATC120的溶出行为分别显着不同，反映了它们在固体中的分子间相互作用。太赫兹能够表明无定形固体 ATC30 和 ATC120 的化学结构之间的差异，它们无法通过 XRD 进行区分。