Pluronics (PEO-PPO-PEO or PPO-PEO-PPO), as the first commercially used polymeric surfactants, designed and manufactured by BASF, have been applied in the development of many pharmaceutical formulations and drug load as well as delivery. Herein, the Williamson ether synthesis reaction was used to prepare hydrophobic monomer fluorinated epichlorohydrin (EPTF) considered as an intermediate state before. In addition, ABA triblock amphiphilic polymers (molecular weight ranging from 2083 to 8888 g/mol with the polymer dispersity index (PDI) lower than 1.52) with a Pluronic-like structure were synthesized by the living cationic polymerization of polyethylene oxide (PEO) and EPTF. The structures of EPTF and polymeric surfactants were characterized by Fourier infrared transform spectroscopy (FI-IR), nuclear magnetic resonance (NMR), and gel permeation chromatography (GPC). Moreover, these kinds of polymeric surfactants can not only reduce the surface tension of water but also self-assemble in water to form micelles with a much lower critical micelle concentration (CMC) ranging from 8.13 × 10^–5 to 1.95 × 10^–3 g/L. Baicalin, low-water-solubility anticancer drug, can be loaded into this polymeric surfactant to form nanomicelles by a solvent evaporation method. The particle size, colloidal stability, and loaded content were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), and ultraviolet–visible (UV–vis) spectrometry. These results indicate that hydrophobic anticancer drugs, like baicalin, can be loaded into these kinds of surfactants with a much higher concentration (maximum 380.776 μg/mL) and excellent storage stability, overcoming their low water solubility so as to increase their therapeutic efficacy.

中文翻译：

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具有类普朗尼克结构的氟化聚合物表面活性剂及其作为药物载体的应用

Pluronics（PEO-PPO-PEO 或 PPO-PEO-PPO）是由巴斯夫设计和制造的第一种商业使用的聚合物表面活性剂，已应用于许多药物配方的开发和载药量以及递送。在此，威廉姆森醚合成反应用于制备疏水性单体氟化环氧氯丙烷（EPTF），之前被认为是一种中间状态。此外，通过聚环氧乙烷（PEO）的活性阳离子聚合合成了具有类Pluronic结构的ABA三嵌段两亲聚合物（分子量范围为2083至8888 g / mol，聚合物分散指数（PDI）低于1.52）和EPTF。EPTF和聚合物表面活性剂的结构通过傅里叶红外变换光谱（FI-IR）、核磁共振（NMR）、和凝胶渗透色谱（GPC）。此外，这些类型的聚合物表面活性剂不仅可以降低水的表面张力，还可以在水中自组装形成临界胶束浓度（CMC）低得多的胶束，范围为 8.13 × 10^–5至 1.95 × 10 ^–3克/升。黄芩苷是一种低水溶性抗癌药物，可以通过溶剂蒸发的方法负载到这种聚合物表面活性剂中形成纳米胶束。通过动态光散射 (DLS)、透射电子显微镜 (TEM) 和紫外-可见 (UV-vis) 光谱法表征粒径、胶体稳定性和负载含量。这些结果表明，黄芩苷等疏水性抗癌药物可以以更高的浓度（最大380.776 μg/mL）和优异的储存稳定性负载到这些表面活性剂中，克服其水溶性低的问题，从而提高其治疗效果。