Rutin, a flavonoid found in fruits and vegetables, is a potential anticancer compound with strong anticancer activity. Therefore, electrochemical sensor was developed for the detection of rutin. In this study, CoWO₄ nanosheets were synthesized via a hydrothermal method, and porous carbon (PC) was prepared via high-temperature pyrolysis. Successful preparation of the materials was confirmed, and characterization was performed by transmission electron microscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. A mixture of PC and CoWO₄ nanosheets was used as an electrode modifier to fabricate the electrochemical sensor for the electrochemical determination of rutin. The 3D CoWO₄ nanosheets exhibited high electrocatalytic activity and good stability. PC has a high surface-to-volume ratio and superior conductivity. Moreover, the hydrophobicity of PC allows large amounts of rutin to be adsorbed, thereby increasing the concentration of rutin at the electrode surface. Owing to the synergistic effect of the 3D CoWO₄ nanosheets and PC, the developed electrochemical sensor was employed to quantitively determine rutin with high stability and sensitivity. The sensor showed a good linear range (5–5000 ng/mL) with a detection limit of 0.45 ng/mL. The developed sensor was successfully applied to the determination of rutin in crushed tablets and human serum samples.

芦丁是一种存在于水果和蔬菜中的类黄酮，是一种潜在的抗癌化合物，具有很强的抗癌活性。因此，开发了用于检测芦丁的电化学传感器。本研究采用水热法合成CoWO _{4纳米片，高温热解制备多孔碳(PC)。}证实了材料的成功制备，并通过透射电子显微镜、扫描电子显微镜和 X 射线光电子能谱进行了表征。PC和CoWO ₄纳米片的混合物用作电极改性剂以制造用于电化学测定芦丁的电化学传感器。3D CoWO ₄纳米片表现出高的电催化活性和良好的稳定性。PC 具有高表面体积比和优异的导电性。此外，PC的疏水性使得大量芦丁被吸附，从而增加了电极表面芦丁的浓度。由于3D CoWO ₄纳米片和PC的协同作用，开发的电化学传感器用于定量测定芦丁，具有高稳定性和灵敏度。该传感器具有良好的线性范围 (5–5000 ng/mL)，检测限为 0.45 ng/mL。开发的传感器成功应用于压碎片剂和人血清样品中芦丁的测定。