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From the soil to the clinic: the impact of microbial secondary metabolites on antibiotic tolerance and resistance
Nature Reviews Microbiology ( IF 88.1 ) Pub Date : 2021-09-16 , DOI: 10.1038/s41579-021-00620-w
Elena K Perry 1 , Lucas A Meirelles 1 , Dianne K Newman 1, 2
Affiliation  

Secondary metabolites profoundly affect microbial physiology, metabolism and stress responses. Increasing evidence suggests that these molecules can modulate microbial susceptibility to commonly used antibiotics; however, secondary metabolites are typically excluded from standard antimicrobial susceptibility assays. This may in part account for why infections by diverse opportunistic bacteria that produce secondary metabolites often exhibit discrepancies between clinical antimicrobial susceptibility testing results and clinical treatment outcomes. In this Review, we explore which types of secondary metabolite alter antimicrobial susceptibility, as well as how and why this phenomenon occurs. We discuss examples of molecules that opportunistic and enteric pathogens either generate themselves or are exposed to from their neighbours, and the nuanced impacts these molecules can have on tolerance and resistance to certain antibiotics.



中文翻译:

从土壤到临床:微生物次生代谢产物对抗生素耐受性和耐药性的影响

次级代谢产物深刻影响微生物生理学、新陈代谢和应激反应。越来越多的证据表明,这些分子可以调节微生物对常用抗生素的敏感性;然而,次级代谢物通常被排除在标准的抗菌药敏试验之外。这可能部分解释了为什么产生次级代谢产物的各种机会性细菌感染经常表现出临床抗菌药敏试验结果与临床治疗结果之间的差异。在这篇综述中,我们探讨了哪些类型的次级代谢物会改变抗菌药物的敏感性,以及这种现象发生的方式和原因。我们讨论机会性和肠道病原体自己产生或从其邻居那里接触到的分子的例子,

更新日期:2021-09-16
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