It is clearly known that psychological stress is an important threat to health in today's modern societies. Recent studies have shown that acute stress causes an increase in positive social behaviours such as prosocial behaviour and devotion which are components of empathic behaviour. Neuropsychiatric manifestations such as anxiety and depression may affect empathic behaviour. The aim of this study was to investigate the effects of chronic restraint stress on empathy-like behaviour and the histopathological changes in the amygdala, prefrontal cortex in the adrenal glands and thymus, as well as the neurochemical pathways associated with empathy, oxytocin and vasopressin. The chronic stress group was subjected to restraint stress daily for 14 days after all subjects were trained to rescue its stressed cagemate using empathy test equipment for 12 days. It was observed that chronic restraint stress had no effect on empathy-like behaviour in rats. Vasopressin levels in amygdala was increased in chronic stress group compared to control group. Anxiety and depression indicators did not change in both groups. In the open field test, control group spent more time in thigmo zone compared to chronic stress group. Adrenal glands relative weights and apoptotic cell ratios were significantly higher in the chronic stress group compared to the control group (expectedly). Although there was no significant difference in behavioral tests, histopathological changes were detected. In subsequent studies, it is appropriate to examine the effects of different types of stress applications, gender-related changes, and other neurochemical pathways associated with stress and empathy.

众所周知，心理压力是当今现代社会对健康的重要威胁。最近的研究表明，急性压力会导致积极的社会行为增加，例如亲社会行为和奉献精神，这些都是移情行为的组成部分。焦虑和抑郁等神经精神症状可能会影响移情行为。本研究的目的是研究慢性约束压力对移情样行为的影响，以及杏仁核、肾上腺和胸腺的前额叶皮层的组织病理学变化，以及与移情、催产素和加压素相关的神经化学通路。慢性应激组在所有受试者接受为期 12 天的同理心测试设备训练后，每天接受约束应激，持续 14 天。据观察，慢性约束压力对大鼠的移情样行为没有影响。与对照组相比，慢性应激组杏仁核中的加压素水平升高。两组的焦虑和抑郁指标没有变化。在旷场测试中，与慢性应激组相比，对照组在 thigmo 区花费的时间更多。与对照组相比，慢性应激组的肾上腺相对重量和凋亡细胞比率显着高于对照组（预期）。尽管在行为测试中没有显着差异，但检测到了组织病理学变化。在随后的研究中，