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The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2021-09-16 , DOI: 10.1016/j.neubiorev.2021.09.028
Win Lee Edwin Wong 1 , Gavin Stewart Dawe 2 , Allan H Young 3
Affiliation  

The relaxin-3/RXFP3 system is one of several neuropeptidergic systems putatively implicated in regulating the behavioural alterations that characterise clinical depression and anxiety, making it a potential target for clinical translation. Accordingly, this systematic review identified published reports on the role of relaxin-3/RXFP3 signalling in these neuropsychiatric disorders and their behavioural endophenotypes, evaluating evidence from animal and human studies to ascertain any relationship. We searched PubMed, EMBASE, PsycINFO and Google Scholar databases up to February 2021, finding 609 relevant records. After stringent screening, 51 of these studies were included in the final synthesis. There was considerable heterogeneity in study designs and some inconsistency across study outcomes. However, experimental evidence is consistent with an ability of relaxin-3/RXFP3 signalling to promote arousal and suppress depressive- and anxiety-like behaviour. Moreover, meta-analyses of six to eight articles investigating food intake revealed that acute RXFP3 activation had strong orexigenic effects in rats. This appraisal also identified the lack of high-quality clinical studies pertinent to the relaxin-3/RXFP3 system, a gap that future research should attempt to bridge.



中文翻译:

松弛素 3/RXFP3 系统在临床抑郁和焦虑中的假定作用:系统文献回顾

松弛素-3/RXFP3 系统是几种神经肽能系统之一,据推测与调节临床抑郁症和焦虑症的行为改变有关,使其成为临床转化的潜在目标。因此,本系统评价确定了有关松弛素 3/RXFP3 信号在这些神经精神疾病及其行为内表型中的作用的已发表报告,评估了动物和人类研究的证据以确定任何关系。我们搜索了截至 2021 年 2 月的 PubMed、EMBASE、PsycINFO 和 Google Scholar 数据库,找到了 609 条相关记录。经过严格筛选,其中 51 项研究被纳入最终合成。研究设计存在相当大的异质性,研究结果之间存在一些不一致。然而,实验证据与松弛素 3/RXFP3 信号传导促进唤醒和抑制抑郁和焦虑样行为的能力一致。此外,对 6 到 8 篇研究食物摄入的文章的荟萃分析表明,急性 RXFP3 激活对大鼠具有强烈的食欲作用。该评估还确定了缺乏与松弛素 3/RXFP3 系统相关的高质量临床研究,这是未来研究应该尝试弥合的差距。

更新日期:2021-09-30
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