Anhedonia has been associated with abnormal reward-related striatal dopamine functioning in patients with different psychiatric disorders. Here, we tested whether anhedonia expression mapped onto striatal volume across several psychiatric diagnoses.

T1-weighted images from 313 participants including 89 healthy controls (HC), 22 patients with opioid use disorder (OUD), 50 patients with major depressive disorder (MDD), 45 patients with borderline personality disorder (BPD), 49 patients with first-episode psychosis (FEP), 43 patients with cocaine use disorder (CUD) and 15 patients with schizophrenia (SZ) were included. Anhedonia was assessed with subscores of the Beck Depression Inventory (BDI) and/or the Scale for the Assessment of Negative Symptoms (SANS). Voxel-based morphometry (VBM) was conducted for identifying dimensional symptom-structure associations using region of interest (ROI, dorsal and ventral striatum) and whole-brain analyses, as well as for group comparisons of striatal volume.

ROI analyses revealed significant negative relationships between putamen volume and BDI and SANS anhedonia scores across OUD, MDD, BPD, CUD and SZ patients (n = 175) and MDD, FEP and SZ patients (n = 114), respectively. Whole-brain VBM analyses confirmed these associations and further showed negative relationships between anhedonia severity and volume of the bilateral cerebellum. There were group differences in right accumbens volume, which however were not related to anhedonia expression across the different diagnoses.

Our findings indicate volumetric abnormalities in the putamen and cerebellum as a common neural substrate of anhedonia severity that cut across psychiatric entities.

在患有不同精神疾病的患者中，快感缺失与异常奖励相关的纹状体多巴胺功能有关。在这里，我们测试了几个精神病诊断中快感缺失的表达是否映射到纹状体体积。

来自 313 名参与者的 T1 加权图像，其中包括 89 名健康对照组 (HC)、22 名阿片类药物使用障碍 (OUD) 患者、50 名重度抑郁症 (MDD) 患者、45 名边缘型人格障碍 (BPD) 患者、49 名首次包括发作性精神病（FEP）、43 名可卡因使用障碍（CUD）患者和 15 名精神分裂症（SZ）患者。快感缺失通过贝克抑郁量表 (BDI) 和/或阴性症状评估量表 (SANS) 的子评分进行评估。使用感兴趣区域（ROI、背侧和腹侧纹状体）和全脑分析以及纹状体体积的组比较，进行基于体素的形态测量 (VBM) 以识别维度症状-结构关联。

ROI 分析显示，OUD、MDD、BPD、CUD 和 SZ 患者（n = 175）和 ​​MDD、FEP 和 SZ 患者（n = 114）的壳核体积与 BDI 和 SANS 快感缺失评分之间存在显着的负相关关系。全脑 VBM 分析证实了这些关联，并进一步显示了快感缺失严重程度与双侧小脑体积之间的负相关关系。右侧伏隔核体积存在组间差异，但与不同诊断的快感缺乏表达无关。

我们的研究结果表明，壳核和小脑的体积异常是快感缺失严重程度的常见神经基质，它跨越了精神实体。