Biofilm-associated Candida infections threaten public health and show high mortality. The drugs used in treatment are very limited due to reasons such as toxicity, low efficacy, and drug resistance, and new alternatives are needed. The use of natural products of plant origin in the biofilm management draws attention. CA (cinnamaldehyde, cinnamic aldehyde, or 3-phenyl-2-propenal) is an essential oil component that can also inhibit mold growth and mycotoxin production. However, there are some limitations in its use due to its poor solubility and volatility in water. Recently, the combination of natural components and nanoparticle-based drug delivery systems shows positive results. In this study, the effects of PLGA (poly(DL-lactide-co-glycolide)) nanoparticles arrested with CA (CA-PLGA NPs) on C. albicans planktonic and biofilm forms (prebiofilm and postbiofilm) were investigated. According to the results, the amount of active ingredient loaded in CA-PLGA NPs is much lower than the free CA and a strong antifungal effect was obtained even at this rate. Also, the postbiofilm application is more effective than prebiofilm application. PLGA NPs can also be a useful carrier for other essential oils, and their potential in various antifungal, antibiofilm, and biomedical applications should be investigated.

生物膜相关的念珠菌感染威胁公共健康并表现出高死亡率。由于毒性、疗效低、耐药等原因，用于治疗的药物非常有限，需要新的替代品。在生物膜管理中使用植物来源的天然产物引起了人们的关注。CA（肉桂醛、肉桂醛或 3-苯基-2-丙烯醛）是一种精油成分，还可以抑制霉菌生长和霉菌毒素的产生。然而，由于其在水中的溶解度和挥发性较差，因此在使用上存在一些限制。最近，天然成分和基于纳米颗粒的药物递送系统的结合显示出积极的结果。在这项研究中，PLGA（聚（DL-丙交酯-共-乙交酯））纳米粒子与 CA（CA-PLGA NPs）对研究了白色念珠菌浮游和生物膜形式（前生物膜和后生物膜）。根据结果​​，负载在 CA-PLGA NPs 中的活性成分的量远低于游离 CA，即使在此速率下也获得了很强的抗真菌作用。此外，后生物膜应用比前生物膜应用更有效。PLGA NPs 也可以作为其他精油的有用载体，应研究它们在各种抗真菌、抗生物膜和生物医学应用中的潜力。