Abstract

The removal of paracetamol pharmaceutical from the aqueous solution by activated carbon prepared from wood sawdust (WSAC) was studied in the current research. The Response Surface Methodology (RSM) was used to model WSAC paracetamol removal, optimize operational parameters, and determine the impact of operational parameters such as adsorbent dosage, initial concentration of paracetamol, and contact time. According to the results of variance analysis (ANOVA), the quadratic model was statistically significant (P < 0.0001), and the determination coefficient value (R²=0.9847) was high. The high determination coefficient value of the quadratic model indicated that the experimental results adapted well with the predicted results, that is, the model was valid for envisaging the experimental results. The optimum conditions were obtained to be 0.16 g/100 mL WSAC dosage, 11.52 mg/L initial paracetamol concentration, and 90.52 min contact time by the desirability function, resulting in the paracetamol removal of 99.24%. The results of the isotherm studies indicated that the isotherm equations of Langmuir, Temkin, and Dubinin all fit the paracetamol adsorption data. The maximum adsorption capacity (q_max) of WSAC was calculated as 15.90 mg/g using the Langmuir isotherm equation. Kinetic study results revealed that the pseudo-second-order kinetic model adapted well to the paracetamol adsorption data.

摘要

本研究研究了以木屑为原料的活性炭（WSAC）从水溶液中去除对乙酰氨基酚药物。响应面方法 (RSM) 用于模拟 WSAC 扑热息痛去除、优化操作参数，并确定吸附剂剂量、扑热息痛初始浓度和接触时间等操作参数的影响。根据方差分析（ANOVA）的结果，二次模型具有统计学意义（P  < 0.0001），决定系数值（R ²=0.9847) 很高。二次模型的高决定系数值表明实验结果与预测结果吻合较好，即该模型对设想实验结果是有效的。最佳条件为 0.16 g/100 mL WSAC 用量、11.52 mg/L 初始扑热息痛浓度和 90.52 min 接触时间，使扑热息痛去除率为 99.24%。等温线研究结果表明，Langmuir、Temkin和Dubinin等温线方程均符合扑热息痛吸附数据。最大吸附容量（q _max) 的 WSAC 使用 Langmuir 等温方程计算为 15.90 mg/g。动力学研究结果表明，准二级动力学模型很好地适应了扑热息痛吸附数据。