Articular cartilage has unique load-bearing properties but has minimal capacity for intrinsic repair. Here, we used three-dimensional weaving, additive manufacturing, and autologous mesenchymal stem cells to create a tissue-engineered, bicomponent implant to restore hip function in a canine hip osteoarthritis model. This resorbable implant was specifically designed to function mechanically from the time of repair and to biologically integrate with native tissues for long-term restoration. A massive osteochondral lesion was created in the hip of skeletally mature hounds and repaired with the implant or left empty (control). Longitudinal outcome measures over 6 months demonstrated that the implant dogs returned to normal preoperative values of pain and function. Anatomical structure and functional biomechanical properties were also restored in the implanted dogs. Control animals never returned to normal and exhibited structurally deficient repair. This study provides clinically relevant evidence that the bicomponent implant may be a potential therapy for moderate hip osteoarthritis.

中文翻译：

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犬髋骨关节炎模型的生物表面置换

关节软骨具有独特的承重特性，但内在修复能力极小。在这里，我们使用三维编织、增材制造和自体间充质干细胞来创建组织工程双组分植入物，以恢复犬髋关节骨关节炎模型的髋关节功能。这种可吸收植入物专门设计用于从修复时开始发挥机械功能，并与天然组织进行生物整合以实现长期修复。在骨骼成熟的猎犬的髋部产生巨大的骨软骨损伤，并用植入物修复或留空（对照）。超过 6 个月的纵向结果测量表明植入狗恢复到正常的术前疼痛和功能值。植入的狗的解剖结构和功能性生物力学特性也得到了恢复。对照动物从未恢复正常，并表现出结构修复缺陷。该研究提供了临床相关证据，表明双组分植入物可能是治疗中度髋骨关节炎的潜在疗法。