当前位置: X-MOL 学术Int. Rev. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
COVID-19 and oral diseases: Assessing manifestations of a new pathogen in oral infections
International Reviews of Immunology ( IF 5 ) Pub Date : 2021-09-16 , DOI: 10.1080/08830185.2021.1967949
Afsar R Naqvi 1 , Joel Schwartz 2 , Daniela Atili Brandini 3 , Samantha Schaller 1 , Heba Hussein 4 , Araceli Valverde 1 , Raza Ali Naqvi 1 , Deepak Shukla 5, 6
Affiliation  

Abstract

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a recently identified virus responsible for life-threatening coronavirus disease 19 (COVID-19). The SARS-CoV-2 infected subjects can be asymptomatic or symptomatic; the later may present a wide spectrum of clinical manifestations. However, the impact of SARS-CoV-2 on oral diseases remain poorly studied. Detection of SARS-CoV-2 in saliva indicates existence of virus in the oral cavity. Recent studies demonstrating the expression of ACE-2, a SARS-CoV-2 entry receptor, in oral tissues further strengthens this observation. Cytokine storm in severe COVID-19 patients and copious secretion of pro-inflammatory cytokines (IL-6, IL-1β and TNF-α) in multiple symptomatic oral pathologies including periodontitis and periapical periodontitis suggests that inflammatory microenvironment is a hallmark of both COVID-19 and oral diseases. Hyperinflammation may provide conducive microenvironment for the growth of local oral pathogens or opportunistic microbes and exert detrimental impact on the oral tissue integrity. Multiple case reports have indicated uncharacterized oral lesions, symptomatic irreversible pulpitis, higher plaque index, necrotizing/desquamative gingivitis in COVID-19 patients suggesting that SARS-CoV-2 may worsen the manifestations of oral infections. However, the underlying factors and pathways remain elusive. Here we summarize current literature and suggest mechanisms for viral pathogenesis of oral dental pathology derived from oral microbiome and oral mucosa-dental tissue interactions. Longitudinal studies will reveal how the virus impairs disease progression and resolution post-therapy. Some relationships we suggest provide the basis for novel monitoring and treatment of oral viral disease in the era of SARS-CoV-2 pandemic, promoting evidence-based dentistry guidelines to diagnose virus-infected patients to improve oral health.



中文翻译:

COVID-19 和口腔疾病:评估新病原体在口腔感染中的表现

摘要

严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 是最近发现的一种病毒,可导致危及生命的冠状病毒病 19 (COVID-19)。感染 SARS-CoV-2 的受试者可以是无症状的或有症状的;后者可能呈现广泛的临床表现。然而,SARS-CoV-2 对口腔疾病的影响仍缺乏研究。在唾液中检测到 SARS-CoV-2 表明口腔中存在病毒。最近的研究表明 ACE-2(一种 SARS-CoV-2 进入受体)在口腔组织中的表达进一步加强了这一观察。重症 COVID-19 患者的细胞因子风暴和大量促炎细胞因子 (IL-6, IL-1β 和 TNF-α)在包括牙周炎和根尖周炎在内的多种口腔疾病症状中表明炎症微环境是 COVID-19 和口腔疾病的标志。过度炎症可能为局部口腔病原体或机会性微生物的生长提供有利的微环境,并对口腔组织的完整性产生不利影响。多例病例报告表明,COVID-19 患者出现无特征的口腔病变、有症状的不可逆牙髓炎、较高的菌斑指数、坏死性/脱屑性牙龈炎,这表明 SARS-CoV-2 可能会加重口腔感染的表现。然而,潜在的因素和途径仍然难以捉摸。在这里,我们总结了当前的文献,并提出了源自口腔微生物组和口腔黏膜 - 牙齿组织相互作用的口腔牙齿病理学病毒发病机制的机制。纵向研究将揭示病毒如何损害疾病进展和治疗后的消退。我们建议的一些关系为 SARS-CoV-2 大流行时代口腔病毒性疾病的新型监测和治疗提供了基础,促进了基于证据的牙科指南来诊断病毒感染的患者以改善口腔健康。

更新日期:2021-09-16
down
wechat
bug